Ogawa N, Mizuno S, Nukina I, Tsukamoto S, Mori A
Brain Res. 1983 Mar 21;263(2):348-50. doi: 10.1016/0006-8993(83)90328-1.
Intraperitoneal injections of thyrotropin releasing hormone (TRH, 6 mg/kg/day) to rats for 14 days resulted in a significant loss (20 25%) of TRH binding sites in the hippocampus, hypothalamus and cerebral cerebral cortex. The TRH-mediated loss was reversible and reflected a decrease in binding sites but no change in affinity. On the other hand, this TRH treatment did not affect the specific brain binding of [3H]QNB. The results suggest that TRH participates in regulating CNS-TRH receptors.
给大鼠腹腔注射促甲状腺激素释放激素（TRH，6毫克/千克/天），持续14天，结果导致海马体、下丘脑和大脑皮层中TRH结合位点显著减少（20%-25%）。TRH介导的减少是可逆的，反映出结合位点减少，但亲和力没有变化。另一方面，这种TRH处理不影响[3H]QNB与大脑的特异性结合。结果表明，TRH参与调节中枢神经系统中的TRH受体。
