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长期给予黄连解毒汤（TJ15）可抑制沙土鼠脑内吲哚胺代谢和毒蕈碱受体结合的缺血诱导变化。

Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the Mongolian gerbil.

作者信息

Kabuto H, Asanuma M, Nishibayashi S, Iida M, Ogawa N

机构信息

Department of Neuroscience, Okayama University Medical School, Japan.

出版信息

Neurochem Res. 1997 Jan;22(1):33-6. doi: 10.1023/a:1027369119224.

DOI:10.1023/a:1027369119224
PMID:9021759
Abstract

We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pre- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.

摘要

我们研究了作为抗脑中风药物的传统汉方制剂黄连解毒汤（TJ15）对这些变化的影响。慢性缺血前后口服TJ15几乎完全消除了缺血诱导的毒蕈碱受体减少和5-羟吲哚乙酸水平升高。这些结果表明，TJ15可预防短暂性缺血诱导的胆碱能突触功能障碍和5-羟色胺能突触前功能亢进。

相似文献

1
Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the Mongolian gerbil.长期给予黄连解毒汤（TJ15）可抑制沙土鼠脑内吲哚胺代谢和毒蕈碱受体结合的缺血诱导变化。
Neurochem Res. 1997 Jan;22(1):33-6. doi: 10.1023/a:1027369119224.
2
Protective effect of oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse.
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3
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The effects of sho-saiko-to-go-keishi-ka-shakuyaku-to (TJ-960) on ischemia-induced changes of brain acetylcholine and monoamine levels in gerbils.柴芍六君子汤合桂枝加芍药汤（TJ-960）对沙土鼠脑缺血诱导的乙酰胆碱和单胺水平变化的影响。
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引用本文的文献

1
Protective effect of oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse.
Neurochem Res. 2000 Feb;25(2):205-9. doi: 10.1023/a:1007515318434.

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