Klincewicz H, Hasik J, Hryniewiecki L
Dtsch Z Verdau Stoffwechselkr. 1983;43(1):22-6.
Patients with ulcers of the stomach and the duodenum were treated with Pirenzepin and the new H2-inhibitor Renitidin. The effects were evaluated on the basis of a double blind trial. After the endoscopic diagnosis repeated examinations were practiced until three weeks after the beginning of the treatment. The best results were found in duodenal ulcers after treatment with Renitidin. 86,6% of the ulcers were healed after 3 weeks of treatment. This results was statistically significant compared with a group of patients treated with a placebo. With gastrozepin 77,2% of patients were successfully treated. In ulcers of the stomach the results were not so good and statistically insignificant. Side effects were not found. Until now it is not possible to decide which substance guarantees better results.
胃溃疡和十二指肠溃疡患者接受了哌仑西平和新型H2抑制剂雷尼替丁的治疗。疗效基于双盲试验进行评估。内镜诊断后，在治疗开始后持续进行复查，直至治疗开始三周后。使用雷尼替丁治疗十二指肠溃疡取得了最佳效果。治疗3周后，86.6%的溃疡愈合。与接受安慰剂治疗的患者组相比，这一结果具有统计学意义。使用胃长宁治疗的患者中有77.2%获得成功治疗。在胃溃疡方面，结果不太理想且无统计学意义。未发现副作用。目前尚无法确定哪种药物能保证更好的疗效。
