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哌仑西平对胃溃疡愈合的影响。一项住院患者的双盲研究(作者译)

[Influence of pirenzepin on healing of gastric ulcer. A double blind study in in-patients (author's transl)].

作者信息

Schmid E, Blaich E

出版信息

Z Gastroenterol. 1978 Dec;16(12):778-80.

PMID:33495
Abstract

In a double-blind study the influence of Pirenzepin on ulcer healing was studied in 28 in-patients with gastric ulcer under endoscopic control. The ulcer size was reduced by Pirenzepin significantly quicker, and the number of ulcers healed after three weeks treatment with Pirenzepin was significantly higher than under placebo. As to accompanying symptoms appetite stimulation was significantly more frequent with Pirenzepin compared to placebo. No patient complained of dryness of the mouth.

摘要

在一项双盲研究中,在内镜控制下,对28例胃溃疡住院患者研究了哌仑西平对溃疡愈合的影响。哌仑西平能显著更快地减小溃疡大小,且用哌仑西平治疗三周后愈合的溃疡数量显著高于安慰剂组。至于伴随症状,与安慰剂相比,哌仑西平引起食欲增加的情况明显更常见。没有患者抱怨口干。

相似文献

1
[Influence of pirenzepin on healing of gastric ulcer. A double blind study in in-patients (author's transl)].哌仑西平对胃溃疡愈合的影响。一项住院患者的双盲研究(作者译)
Z Gastroenterol. 1978 Dec;16(12):778-80.
2
Pirenzepine in the treatment of gastric ulcer. A double-blind short-term clinical trial.哌仑西平治疗胃溃疡。一项双盲短期临床试验。
Scand J Gastroenterol Suppl. 1979;57:51-5.
3
Pirenzepin in gastric and duodenal ulcer: a double-blind trial.哌仑西平治疗胃及十二指肠溃疡:一项双盲试验。
J Int Med Res. 1981;9(2):148-51. doi: 10.1177/030006058100900212.
4
[Comparative treatment of gastric ulcer with pirenzepin, cimetidine and placebo].[哌仑西平、西咪替丁与安慰剂治疗胃溃疡的对比研究]
Rev Med Chil. 1985 Jun;113(6):537-40.
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Pirenzepine in the treatment of duodenal ulcer.哌仑西平治疗十二指肠溃疡。
Scand J Gastroenterol Suppl. 1979;57:41-4.
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Pirenzepine (LS 519) in severe duodenal ulcer and in gastric ulcer. A double-blind clinical trial.哌仑西平(LS 519)治疗重度十二指肠溃疡和胃溃疡。一项双盲临床试验。
Scand J Gastroenterol Suppl. 1979;57:33-9.
7
Comparison of pirenzepine and carbenoxolone in the treatment of chronic gastric ulcer. A double-blind endoscopic trial.哌仑西平和甘珀酸治疗慢性胃溃疡的比较。一项双盲内镜试验。
Hepatogastroenterology. 1985 Dec;32(6):293-5.
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[Experiences with Pirenzepin in the therapy of peptic ulcers (author's transl)].哌仑西平治疗消化性溃疡的经验(作者译)
Wien Med Wochenschr. 1979 Oct 10;129(18):513-6.
9
Therapeutic effect of pirenzepine dihydrochloride on gastric ulcer evaluated by a double-blind controlled clinical study. Phase III study.通过双盲对照临床研究评估盐酸哌仑西平对胃溃疡的治疗效果。III期研究。
Arzneimittelforschung. 1982;32(5):556-65.
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Pirenzepine in the treatment of benign gastroduodenal diseases. A double-blind controlled clinical trial.哌仑西平治疗良性胃十二指肠疾病。一项双盲对照临床试验。
Scand J Gastroenterol Suppl. 1979;57:25-31.

引用本文的文献

1
Pirenzepine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in peptic ulcer disease and other allied diseases.哌仑西平。其药效学和药代动力学特性以及在消化性溃疡疾病和其他相关疾病中的治疗效果综述。
Drugs. 1985 Aug;30(2):85-126. doi: 10.2165/00003495-198530020-00001.