多发性硬化症：γ-亚麻酸给药对细胞膜的影响以及不饱和脂肪酸进行长期临床试验的必要性。
Multiple sclerosis: effect of gamma linolenate administration upon membranes and the need for extended clinical trials of unsaturated fatty acids.
作者信息
Field E J, Joyce G
出版信息
Eur Neurol. 1983;22(1):78-83. doi: 10.1159/000115540.
PMID:6301844
Abstract
Electrophoretic mobility studies of red blood cells from subjects with multiple sclerosis indicate that treatment with unsaturated fatty acids must continue for at least 2 years before normal reactivity is restored by currently available tests. If this applies to myelin also, then clinical trials aimed at treating the recognized multiple sclerosis subject by polyunsaturated fatty acids really begin after 2 years, and this should be recognized when a trial program is drawn up.
摘要
对患有多发性硬化症患者的红细胞进行的电泳迁移率研究表明，使用不饱和脂肪酸进行治疗必须持续至少两年，才能通过目前可用的检测恢复正常反应性。如果这也适用于髓磷脂，那么旨在用多不饱和脂肪酸治疗已确诊的多发性硬化症患者的临床试验实际上要在两年后才真正开始，在制定试验方案时应认识到这一点。
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