人类嗜碱性粒细胞和肥大细胞的比较研究。

Comparative studies of human basophils and mast cells.

作者信息

MacGlashan D W, Schleimer R P, Peters S P, Schulman E S, Adams G K, Sobotka A K, Newball H H, Lichtenstein L M

出版信息

Fed Proc. 1983 May 15;42(8):2504-9.

Abstract

Atopic disease in humans results primarily from the activity of tissue mast cells and circulating basophils. These two very similar cell types have recently been purified to near homogeneity and studies have begun to identify the biochemical mechanisms of mediator release, to explore the effects of pharmacologic manipulation of the response, and to determine unambiguously which mediators are derived from mast cells and basophils. This report will review studies examining various parameters of histamine release, the role of cyclic AMP in histamine release, and the production of arachidonic acid metabolites and their pharmacologic modulation.

摘要

人类的特应性疾病主要源于组织肥大细胞和循环嗜碱性粒细胞的活动。这两种非常相似的细胞类型最近已被纯化至近乎同质，并且研究已开始确定介质释放的生化机制，探索对该反应进行药理操作的效果，并明确确定哪些介质源自肥大细胞和嗜碱性粒细胞。本报告将综述研究组胺释放的各种参数、环磷酸腺苷在组胺释放中的作用、花生四烯酸代谢产物的产生及其药理调节。