Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Adv Immunol. 2012;115:141-59. doi: 10.1016/B978-0-12-394299-9.00005-9.
CD4(+) T-helper type 2 (Th2) cells, characterized by their expression of interleukin (IL)-4, IL-5, IL-9, and IL-13, are required for immunity to helminth parasites and promote the pathological inflammation associated with asthma and allergic diseases. Recent reports from a number of laboratories have indicated that basophils can influence the induction and/or effector stages of Th2 cytokine-mediated inflammation. However, the impact of basophils appears to depend on the anatomical location and nature of the infectious or inflammatory stimulus. This review highlights the factors that regulate basophil development and activation and describes known basophil effector functions. Further, we discuss the recent identification of phenotypic and functional heterogeneity within murine and human basophil populations and discuss how these findings may explain the context-dependent influence of basophils on either the propagation, regulation, or effector phases of Th2 cytokine-associated inflammation.
CD4(+) T-helper type 2 (Th2) 细胞，其特征在于表达白细胞介素 (IL)-4、IL-5、IL-9 和 IL-13，是对寄生虫免疫所必需的，并且促进与哮喘和过敏性疾病相关的病理性炎症。来自多个实验室的最近报告表明，嗜碱性粒细胞可以影响 Th2 细胞因子介导的炎症的诱导和/或效应阶段。然而，嗜碱性粒细胞的影响似乎取决于感染或炎症刺激的解剖位置和性质。这篇综述强调了调节嗜碱性粒细胞发育和激活的因素，并描述了已知的嗜碱性粒细胞效应功能。此外，我们讨论了最近在鼠类和人类嗜碱性粒细胞群体中鉴定的表型和功能异质性，并讨论了这些发现如何解释嗜碱性粒细胞对 Th2 细胞因子相关炎症的传播、调节或效应阶段的依赖于上下文的影响。
