Institute for Immunology, Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ann N Y Acad Sci. 2011 Jan;1217:166-77. doi: 10.1111/j.1749-6632.2010.05918.x.
Recent studies indicate that basophils perform essential functions in multiple models of Th2 cytokine-dependent immunity and inflammation. In addition to their role as late phase effector cells, basophil populations can express MHC class II and costimulatory molecules, migrate into draining lymph nodes, present antigen to naive CD4(+) T cells, and promote Th2 cell differentiation. In this context, basophils have been shown to contribute to the induction and propagation of Th2 cytokine responses following exposure to some helminth parasites or allergens. In this review, we discuss recent studies that provide new insights into basophil development, regulation, and effector function. In addition, we discuss the ability of basophils to act both independently and cooperatively with dendritic cells to support Th2 cytokine-mediated inflammation.
最近的研究表明，嗜碱性粒细胞在多种 Th2 细胞因子依赖性免疫和炎症模型中发挥重要功能。除了作为晚期效应细胞的作用外，嗜碱性粒细胞群体还可以表达 MHC Ⅱ类和共刺激分子，迁移到引流淋巴结，向幼稚 CD4(+)T 细胞呈递抗原，并促进 Th2 细胞分化。在这种情况下，已经表明嗜碱性粒细胞有助于在暴露于某些寄生虫或过敏原后诱导和传播 Th2 细胞因子反应。在这篇综述中，我们讨论了最近的研究，这些研究为嗜碱性粒细胞的发育、调节和效应功能提供了新的见解。此外，我们还讨论了嗜碱性粒细胞独立或与树突状细胞协同作用以支持 Th2 细胞因子介导的炎症的能力。
