促甲状腺激素对囊泡转运和甲状腺滤泡形态发生的影响：大鼠的体视学研究

Thyrotropin effects on vesicle transfer and thyroid follicle morphogenesis: a stereological study in the rat.

作者信息

Remy L, Penel C, Rua S, Mazzella E, Michel-Bechet M

出版信息

Biol Cell. 1983;49(2):145-52. doi: 10.1111/j.1768-322x.1984.tb00232.x.

DOI:10.1111/j.1768-322x.1984.tb00232.x

Abstract

Incubation in a culture medium with and without TSH of 16 day-old foetal thyroid glands induces hypertrophy of the Golgi apparatus which may be correlated with a considerable increase in the number of secretory vesicles. A stereological study performed during the first 6 hr of incubation showed that: vesicle secretion was biphasic; vesicle secretion was heterogeneous with two different populations of vesicles; When TSH (20 mU and 80 mU) was added to the medium, the volume density of the follicular lumina increased; at least during the first 6 hr TSH seemed to be necessary to the formation of follicular lumina.

摘要

在含有和不含促甲状腺激素（TSH）的培养基中培养16日龄胎儿甲状腺，会诱导高尔基体肥大，这可能与分泌小泡数量的显著增加有关。在培养的前6小时进行的体视学研究表明：小泡分泌是双相的；小泡分泌是异质性的，存在两种不同类型的小泡；当向培养基中添加促甲状腺激素（20 mU和80 mU）时，滤泡腔的体积密度增加；至少在最初6小时内，促甲状腺激素似乎是滤泡腔形成所必需的。