Reddy M M, Bures J
Neurosci Lett. 1980 May 1;17(3):243-7. doi: 10.1016/0304-3940(80)90030-0.
Waves of spreading depression (SD) no not penetrate into an electrically stimulated (10 Hz, 0.05 msec, 20-30 V) cortical area of rats. The blockade develops slowly and is proportional to the (K+)e increase in the stimulated cortex. After cessation of stimulation, (K+)e returns to the resting level within 20-30 sec, but the SD blockade continues for 2-3 min. It is suggested that the stimulation induced activation of a metabolic pump disrupts the autoregenerative mechanism of SD propagation by enhancing K+ reabsorption into neurons.
扩散性抑制（SD）波不会侵入经电刺激（10赫兹，0.05毫秒，20 - 30伏）的大鼠皮质区域。这种阻断作用发展缓慢，且与受刺激皮质中细胞外钾离子（K⁺）e的增加成正比。刺激停止后，细胞外钾离子（K⁺）e在20 - 30秒内恢复到静息水平，但SD阻断作用会持续2 - 3分钟。据推测，刺激诱导的代谢泵激活通过增强钾离子向神经元的重吸收，破坏了SD传播的自我再生机制。
