Nunoda S, Mimo N, Kitano H, Kyoi M, Hifumi S, Ueno T, Takeda R, Nakanuma Y
Am J Gastroenterol. 1983 May;78(5):301-4.
We describe a case of hepatocellular carcinoma in a 16-year-old boy whose mother, aunts, uncles, and cousins had liver dysfunction associated with HBs-Ag. Postmortem examination in this case revealed a hepatocellular carcinoma with a trabecular and partially pseudoglandular pattern involving the whole left and most of the right lobe, associated with liver cirrhosis of the postnecrotic type. Postmortem examination of the liver revealed numerous HBs-Ag positive hepatocytes demonstrated by Orcein staining in the nontumorous cirrhotic area, but not in the tumorous hepatocytes. Vertical transmission of HBV from his mother to the patient was suspected, and autopsy findings revealed continuous infection of HBV. Hepatocellular carcinoma in a young patient, especially when associated with HBs-Ag positive liver cirrhosis, as described here is rare in the English and Japanese literature.
我们描述了一例16岁男孩的肝细胞癌病例，其母亲、阿姨、叔叔和表亲均有与乙肝表面抗原（HBs-Ag）相关的肝功能障碍。该病例的尸检显示，肝细胞癌呈小梁状且部分为假腺管状结构，累及整个左叶及大部分右叶，伴有坏死后型肝硬化。肝脏尸检发现，在非肿瘤性肝硬化区域，经地衣红染色显示有大量乙肝表面抗原阳性肝细胞，但肿瘤性肝细胞中未发现。怀疑乙肝病毒（HBV）从其母亲垂直传播给患者，尸检结果显示存在HBV持续感染。如本文所述，年轻患者发生肝细胞癌，尤其是与乙肝表面抗原阳性肝硬化相关的情况，在英文和日文文献中均较为罕见。
