[乙肝表面抗原阳性肝细胞癌（病理形态学研究）]
[HBS Ag-positive hepatocellular cancer (pathomorphologic study)].
作者信息
Bardadin K, Kobushevska-Farina M
出版信息
Arkh Patol. 1979;41(8):45-9.
Pathomophological and histochemical analysis of 7 autopsy cases of primary hepatocellular carcinoma was performed. Direct immunofluorescence with an anti-HBsAg serum and staining with orsein according to Shikata's method revealed the presence of HBsAg in hepatocytes of the cirrhotic tissue and in tumour cells. Cirrhotic nodes were found to have numerous HBsAg-positive cells, whereas in the tumour tissue the number of such cells was insignificant and they were found only in highly differentiated areas. In all cases, highly differentiated hepatocellular carcinoma was combined with active large nodular cirrhosis.
对7例原发性肝细胞癌尸检病例进行了病理形态学和组织化学分析。用抗HBsAg血清进行直接免疫荧光检测，并按照Shikata方法用奥新染色，结果显示在肝硬化组织的肝细胞和肿瘤细胞中存在HBsAg。发现肝硬化结节中有大量HBsAg阳性细胞，而在肿瘤组织中，此类细胞数量较少，仅在高分化区域发现。在所有病例中，高分化肝细胞癌均合并有活动性大结节性肝硬化。
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