Nordheim A, Rich A
Nature. 1983;303(5919):674-9. doi: 10.1038/303674a0.
Three 8-base pair (bp) segments of alternating purine-pyrimidine from the simian virus 40 enhancer region form Z-DNA on negative supercoiling; minichromosome DNase I-hypersensitive sites determined by others bracket these three segments. A survey of transcriptional enhancer sequences reveals a pattern of potential Z-DNA-forming regions which occur in pairs 50-80 bp apart. This may influence local chromatin structure and may be related to transcriptional activation.
来自猿猴病毒40增强子区域的三个8碱基对（bp）的嘌呤-嘧啶交替片段在负超螺旋作用下形成Z-DNA；其他人确定的微型染色体DNA酶I超敏位点将这三个片段包围起来。对转录增强子序列的调查揭示了一种潜在的Z-DNA形成区域模式，这些区域以相隔50 - 80 bp的成对形式出现。这可能会影响局部染色质结构，并且可能与转录激活有关。
