Prickett J D, Robinson D R, Steinberg A D
Trans Assoc Am Physicians. 1982;95:145-54.
A diet containing menhaden oil, rich in EPA, protected (NZB x NZW) F1 mice from developing lupus nephritis. Only 16% of mice treated with this diet from 5-6 weeks of age developed severe renal disease by 19 months of age, as opposed to 100% of controls. The menhaden oil diet, when delayed until mice were 5 months of age, also reduced the incidence of renal disease, and under these conditions anti-n-DNA and anti-ss-DNA antibodies were similar in treated and control groups. We suggest that EPA, an AA analogue, may reduce inflammation by altering the production of PGs and LTs.
富含二十碳五烯酸（EPA）的鲱鱼油饮食可保护（新西兰黑鼠×新西兰白鼠）F1代小鼠不发生狼疮性肾炎。从5至6周龄开始用这种饮食喂养的小鼠，到19月龄时只有16%发生严重肾病，而对照组的这一比例为100%。鲱鱼油饮食若推迟到小鼠5月龄时开始，也可降低肾病发病率，在此条件下，治疗组和对照组的抗双链DNA和抗单链DNA抗体相似。我们认为，作为花生四烯酸（AA）类似物的EPA可能通过改变前列腺素（PGs）和白三烯（LTs）的生成来减轻炎症。
