Palestine R F, Su W P, Liesegang T J
Arch Dermatol. 1983 Jul;119(7):580-6.
Late-onset chronic mucocutaneous candidiasis (CMCC) is part of a spectrum of candidal infections. It usually develops during or after the fourth decade of life and is often associated with an underlying neoplasm, especially thymoma. A 56-year-old man with late-onset CMCC and thymoma had several unusual features. His malignant thymoma seemed to be more widespread than the thymomas of previously described patients. Ocular infection was present in addition to extensive involvement of the skin, nails, and oral mucosa. To our knowledge, this is the first report of ocular involvement in this syndrome. We also believe that this is the first patient with thymoma-associated late-onset CMCC to be treated effectively with ketoconazole.
迟发性慢性黏膜皮肤念珠菌病（CMCC）是念珠菌感染谱的一部分。它通常在生命的第四个十年期间或之后发病，并且常与潜在的肿瘤相关，尤其是胸腺瘤。一名患有迟发性CMCC和胸腺瘤的56岁男性有几个不寻常的特征。他的恶性胸腺瘤似乎比先前描述的患者的胸腺瘤分布更广。除了皮肤、指甲和口腔黏膜广泛受累外，还存在眼部感染。据我们所知，这是该综合征眼部受累的首例报告。我们还认为，这是首例用酮康唑有效治疗的与胸腺瘤相关的迟发性CMCC患者。
