Collier L H, Scott Q J, Pani A
J Gen Virol. 1983 Jul;64 (Pt 7):1483-90. doi: 10.1099/0022-1317-64-7-1483.
By several criteria, replication of herpes simplex virus type 1 (HSV-1) in primary cell cultures from inbred strains of mice resistant (R) to this virus was less than in cultures from susceptible (S) strains. The difference was not obviously related to less efficient adsorption, to more efficient production of interferon or to a larger number of lysosomes. Except at high multiplicities of infection, cells from the F1 progeny of a cross between an R and an S strain replicated virus as well as cells from the S parent; this contrasts with strain-related resistance to intraperitoneal inoculation in vivo, which is inherited as a dominant characteristic. It is suggested that diminished ability of structural cells to replicate HSV-1 may contribute to resistance in the intact animal.
根据多项标准，1型单纯疱疹病毒（HSV-1）在对该病毒具有抗性（R）的近交系小鼠原代细胞培养物中的复制量少于在易感（S）品系的培养物中的复制量。这种差异与吸附效率较低、干扰素产生效率较高或溶酶体数量较多没有明显关系。除了在高感染复数时，R品系和S品系杂交的F1后代细胞与S品系亲代细胞一样能复制病毒；这与体内对腹腔接种的品系相关抗性形成对比，后者作为显性特征遗传。有人提出，结构细胞复制HSV-1的能力降低可能有助于完整动物的抗性。
