Osborne M R, Harvey R G, Brookes P
Chem Biol Interact. 1978 Jan;20(1):123-30. doi: 10.1016/0009-2797(78)90087-x.
The reaction of trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (anti-BPDE) with DNA prelabelled with [14C] and [3H]-purine precursors has indicated that in addition to the N2-position of guanine previously reported [10--12] reaction also involves the N7-position of guanine. The hydrocarbon-N7-guanine product was not detected earlier because it is lost from the DNA very readily at pH 7. The same N7-product was obtained by reaction of anti-BPDE with guanine in dimethylformamide.
反式-7,8-二羟基-反式-9,10-环氧-7,8,9,10-四氢苯并[a]芘（反式-BPDE）与预先用[14C]和[3H]嘌呤前体标记的DNA反应表明，除了先前报道的鸟嘌呤N2位[10-12]外，反应还涉及鸟嘌呤的N7位。烃-N7-鸟嘌呤产物此前未被检测到，因为它在pH 7时很容易从DNA中丢失。通过反式-BPDE与二甲基甲酰胺中的鸟嘌呤反应也得到了相同的N7产物。
