Base specificity in the binding of benzo[a]pyrene diol epoxide to simian virus 40 DNA.
作者信息
Mengle L, Gamper H, Bartholomew J
出版信息
Cancer Lett. 1978 Sep;5(3):131-7. doi: 10.1016/s0304-3835(78)80029-9.
PMID:210927
Abstract
[14C]Simian virus 40 (SV40) DNA was reacted with [3H]7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene to give 0.60 adducts per genome. The modified DNA was digested to completion with Hind III restriction endonuclease and the 6 fragments isolated by polyacrylamide gel electrophoresis. Hydrocarbon binding to the fragments was proportional to their guanine--cytosine (G--C) content, reflecting selective reaction of the hydrocarbon with deoxyguanosine residues. No sites unusually susceptible to alkylation were detected.
摘要
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引用本文的文献
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DNA alkylation and unwinding induced by benzo[a]pyrene diol epoxide: modulation by ionic strength and superhelicity.苯并[a]芘二醇环氧化物诱导的DNA烷基化和解旋：离子强度和超螺旋的调节作用
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2000-4. doi: 10.1073/pnas.77.4.2000.
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