单纯疱疹性脑炎：通过病毒分离株的限制性内切酶图谱分析一组病例

Herpes simplex encephalitis: analysis of a cluster of cases by restriction endonuclease mapping of virus isolates.

作者信息

Landry M L, Berkovits N, Summers W P, Booss J, Hsiung G D, Summers W C

出版信息

Neurology. 1983 Jul;33(7):831-5. doi: 10.1212/wnl.33.7.831.

DOI:10.1212/wnl.33.7.831

Abstract

In December 1979, there were three deaths from culture-proven herpes encephalitis in 3 weeks in the New Haven area, and a nurse caring for one of these patients developed a herpetic lesion on her nose. The three brain isolates, the isolate from the nurse, and several epidemiologically unrelated strains were analyzed by restriction endonuclease mapping. All were determined to be distinct strains of herpes simplex virus. The possibility that a single strain of virus caused this cluster of cases was therefore examined directly and disproved.

摘要

1979年12月，纽黑文地区在3周内有3例经培养证实的疱疹性脑炎死亡病例，一名护理其中一名患者的护士鼻子上出现了疱疹性损伤。对这三例脑部分离株、该护士的分离株以及几种流行病学上无关的菌株进行了限制性内切酶图谱分析。结果确定所有菌株均为单纯疱疹病毒的不同菌株。因此，直接对单一病毒株导致这一系列病例的可能性进行了研究，并予以否定。