布氏锥虫动基体DNA的主要转录本是非常小的核糖体RNA。
The major transcripts of the kinetoplast DNA of Trypanosoma brucei are very small ribosomal RNAs.
作者信息
Eperon I C, Janssen J W, Hoeijmakers J H, Borst P
出版信息
Nucleic Acids Res. 1983 Jan 11;11(1):105-25. doi: 10.1093/nar/11.1.105.
The nucleotide sequence has been determined of a 2.2 kb segment of kinetoplast DNA, which encodes the major mitochondrial transcripts (12S and 9S) of Trypanosoma brucei. The sequence shows that the 12S RNA is a large subunit rRNA, although sufficiently unusual for resistance to chloramphenicol to be predicted. The 9S RNA has little homology with other rRNAs, but a possible secondary structure is not unlike that of the 2.5-fold larger E. coli 16S rRNA. We conclude that the 12S RNA (about 1230 nucleotides) and the 9S RNA (about 640 nucleotides) are the smallest homologues of the E. coli 23S and 16S rRNAs yet observed.
已经确定了布氏锥虫动质体DNA 2.2 kb片段的核苷酸序列，该片段编码布氏锥虫的主要线粒体转录本（12S和9S）。序列显示12S RNA是一种大亚基rRNA，尽管其足够特别以至于可以预测它对氯霉素具有抗性。9S RNA与其他rRNA几乎没有同源性，但其可能的二级结构与大2.5倍的大肠杆菌16S rRNA的二级结构并无不同。我们得出结论，12S RNA（约1230个核苷酸）和9S RNA（约640个核苷酸）是迄今为止观察到的与大肠杆菌23S和16S rRNA最小的同源物。
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