Lin J C, Smith M C, Cheng Y C, Pagano J S
Science. 1983 Aug 5;221(4610):578-9. doi: 10.1126/science.6306771.
Epstein-Barr virus (EBV) is the cause of infectious mononucleosis and is associated with three human malignancies. Acyclovir [9-(2-hydroxyethoxymethyl)guanine], the first clinically useful drug effective against replication of EBV, is without effect against latent or persistent EBV infection. Three nucleoside analogs, E-5-(2-bromovinyl)-2'-deoxyuridine, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine, and 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil are potent inhibitors of EBV replication in vitro. Moreover, in contrast to the reversibility of viral inhibition by Acyclovir, these three drugs have prolonged effects in suppressing viral replication even after the drugs are removed from persistently infected cell cultures.
爱泼斯坦-巴尔病毒（EBV）是传染性单核细胞增多症的病因，并且与三种人类恶性肿瘤相关。阿昔洛韦[9-(2-羟乙氧甲基)鸟嘌呤]是第一种临床上有效的抗EBV复制的药物，但对潜伏或持续性EBV感染无效。三种核苷类似物，即E-5-(2-溴乙烯基)-2'-脱氧尿苷、1-(2-脱氧-2-氟-β-D-阿拉伯呋喃糖基)-5-碘胞嘧啶和1-(2-脱氧-2-氟-β-D-阿拉伯呋喃糖基)-5-甲基尿嘧啶，在体外是EBV复制的强效抑制剂。此外，与阿昔洛韦对病毒抑制的可逆性不同，即使在将这些药物从持续感染的细胞培养物中去除后，这三种药物在抑制病毒复制方面仍有持久的效果。
