López-Burillo S, Alvarez-Rodríguez Y, Valladares Y
Rev Esp Oncol. 1980;27(1):7-27.
The amount of rough endoplasmic reticulum (RER) and associated polyribosomes changes during the cell cycle. We describe here the amount and activity of free and RER-bound ribosomes of Ehrlich ascites cancer cells. RER does not exist during the G1, G2 and M phases, it appears in the early S phase and decreases in the second half of S. The formation of RER during the S phase and the S phase RER-found ribosomes may be related to the biosynthesis of histones, some fundamental non-histonic nuclear proteins, and enzymes involved in DNA replication and several metabolic reactions.
