Alva-Valdes R, Glock R D, Kluge J P, Keune C M
Am J Vet Res. 1983 Apr;44(4):588-95.
The effects of vaccination against pseudorabies virus (PRV) infection were studied in 93 barrows. Commercial attenuated and inactivated PRV vaccines were used. The protection provided was evaluated by the comparison of clinical signs, gross lesions, and microscopic lesions among vaccinated and nonvaccinated pigs after challenge exposure with a sublethal dose of PRV. Histopathologic changes are described for the CNS and other tissues. Neither the modified live- nor the inactivated-PRV vaccines prevented clinical signs or microscopic lesions in pigs after challenge exposure. However, both vaccines diminished the severity of clinical signs and microscopic lesions in the animals for a period of up to 8 months after they were vaccinated. Protection against clinical signs and microscopic lesions was absent in the pigs 10 months after the vaccination.
在93头公猪中研究了接种疫苗预防伪狂犬病病毒（PRV）感染的效果。使用了市售的减毒和灭活PRV疫苗。通过比较接种疫苗和未接种疫苗的猪在接受亚致死剂量PRV攻击暴露后的临床症状、大体病变和微观病变来评估所提供的保护作用。描述了中枢神经系统和其他组织的组织病理学变化。无论是改良活疫苗还是灭活PRV疫苗，都不能预防猪在攻击暴露后出现临床症状或微观病变。然而，两种疫苗在接种后的长达8个月时间内都减轻了动物临床症状和微观病变的严重程度。接种疫苗10个月后，猪对临床症状和微观病变没有保护作用。
