Pensaert M B, Vandeputte J, Andries K
Res Vet Sci. 1982 Jan;32(1):12-6.
Groups of pigs from vaccinated and unvaccinated sows were vaccinated once or twice between the ages of eight and 20 weeks with a commercial inactivated, oil adjuvanted Aujeszky's disease virus vaccine. Pigs were challenged by the oronasal route when 22 to 27 weeks old. Pigs from unvaccinated sows developed neutralising antibodies after vaccination but no seroconversion was detected in eight-week-old pigs or in 80 per cent of 15-week-old pigs from vaccinated sows. Challenge resulted in severe disease and weight loss in control pigs. In vaccinated animals the duration and severity of clinical signs and the amount of weight lost decreased with increasing serum neutralisation titres. The results indicate that parenteral vaccination at weaning with the vaccine described will not protect pigs at slaughter age against infection and disease, particularly if they were born from seropositive mothers.
将来自接种过疫苗和未接种疫苗母猪的猪群，在8至20周龄之间用市售的灭活油佐剂伪狂犬病病毒疫苗接种一次或两次。猪在22至27周龄时通过口鼻途径进行攻毒。来自未接种疫苗母猪的猪在接种疫苗后产生了中和抗体，但在8周龄的猪或来自接种疫苗母猪的15周龄猪中的80%未检测到血清转化。攻毒导致对照猪出现严重疾病和体重减轻。在接种疫苗的动物中，随着血清中和滴度的增加，临床症状的持续时间和严重程度以及体重减轻的量都有所减少。结果表明，用所述疫苗在断奶时进行肌肉注射接种，不能保护屠宰年龄的猪免受感染和疾病，特别是如果它们是由血清阳性的母猪所生。
