Smith K O, Galloway K S, Hodges S L, Ogilvie K K, Radatus B K, Kalter S S, Heberling R L
Am J Vet Res. 1983 Jun;44(6):1032-5.
The following members of the Herpetoviridae family were tested to determine their sensitivities to the new antiviral drug, BIOLF-62: equine herpesvirus types 1 and 3, human herpesvirus types 1 and 2, swine herpesvirus, bovine herpesvirus type 4, feline herpesvirus, canine herpesvirus, and herpes simiae virus. Equine herpesviruses 1 and 3, human herpesviruses 1 and 2, and herpes simiae virus were all sensitive to BIOLF-62 at concentrations of less than 0.55 micrograms/ml. Equine herpesvirus types 1 and 3 were particularly sensitive, viral median effective dose (ED50) concentrations of the drug being only 0.033 and 0.16 micrograms/ml, respectively. Such high antiviral potency and low cell toxicity indicate that BIOLF-62 might be useful in the treatment of infected animals.
对疱疹病毒科的以下成员进行了测试，以确定它们对新型抗病毒药物BIOLF-62的敏感性：1型和3型马疱疹病毒、1型和2型人疱疹病毒、猪疱疹病毒、4型牛疱疹病毒、猫疱疹病毒、犬疱疹病毒和猴疱疹病毒。1型和3型马疱疹病毒、1型和2型人疱疹病毒以及猴疱疹病毒在浓度低于0.55微克/毫升时均对BIOLF-62敏感。1型和3型马疱疹病毒尤其敏感，该药物的病毒半数有效剂量（ED50）浓度分别仅为0.033和0.16微克/毫升。如此高的抗病毒效力和低细胞毒性表明BIOLF-62可能对治疗受感染动物有用。
