抗疱疹药物在不同细胞系中的比较疗效。
Comparative efficacy of antiherpes drugs in different cell lines.
作者信息
De Clercq E
出版信息
Antimicrob Agents Chemother. 1982 Apr;21(4):661-3. doi: 10.1128/AAC.21.4.661.
Abstract
A selection of antiherpes compounds including bromovinyldeoxyuridine (BVDU), acyclovir (ACV), and fluoroiodoaracytosine (FIAC) were compared for their inhibitory effects on herpes simplex virus type 1 (strain KOS) replication in a wide variety of human, simian, feline, and murine cell lines. The 50% inhibitory doses of the compounds varied considerably from one cell line to another, i.e., from 0.01 to 2 micrograms/ml for ACV and from 0.004 to 0.2 micrograms/ml for BVDU and FIAC. However, the relative order of antiviral potency remained constant, thus (in order of decreasing potency) BVDU greater than FIAC greater than ACV, for all cell lines studied except for the murine embryo cells, in which the order of decreasing potency was BVDU greater than ACV greater than FIAC, and for the feline lung cells, in which the order of decreasing potency was FIAC greater than ACV greater than BVDU.
摘要
比较了一系列抗疱疹化合物，包括溴乙烯脱氧尿苷（BVDU）、阿昔洛韦（ACV）和氟碘阿糖胞苷（FIAC）对单纯疱疹病毒1型（KOS株）在多种人、猴、猫和鼠细胞系中复制的抑制作用。这些化合物的50%抑制剂量在不同细胞系中差异很大，即ACV为0.01至2微克/毫升，BVDU和FIAC为0.004至0.2微克/毫升。然而，抗病毒效力的相对顺序保持不变，因此（按效力递减顺序）在除鼠胚胎细胞（其中效力递减顺序为BVDU大于ACV大于FIAC）和猫肺细胞（其中效力递减顺序为FIAC大于ACV大于BVDU）之外的所有研究细胞系中，BVDU大于FIAC大于ACV。
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