Furman K I, Gomperts E D, Hockley J
Clin Nephrol. 1978 Jan;9(1):15-8.
A pharmacokinetic study of intraperitoneal heparin was undertaken in eleven chronic renal failure patients as a guide for its therapeutic use in peritoneal dialysis. The intraperitoneal heparin was assayed as the activated-partial-thromboplastin time (A-PTT) of peritoneal aspirate or outflow dialyzate added to control plasma. This was noted to decay relatively slowly, the mean t 1/2 of heparin in the peritoneal cavity being 10.8 +/- 0.93 hr. The heparin cofactor antithrombin III determined by both immunological and functional methods was found to be present in low concentration in residual peritoneal fluid aspirated prior to commencing dialysis. Generally this was less than one-third of normal plasma values, and with the repeated dilution and outflow sequences of dialysis the cofactor concentrations rapidly fell to negligible levels that were incapable of activating any heparin present. Systemic blood coagulation was unaffected by single 10000 U doses of heparin administered intraperitoneally in that plasma A-PTT values were not lengthened when measured over the ensuing six hours.
对11名慢性肾衰竭患者进行了腹膜内肝素的药代动力学研究，以指导其在腹膜透析中的治疗应用。腹膜内肝素通过将腹膜吸出液或流出透析液加入对照血浆后的活化部分凝血活酶时间（A-PTT）进行测定。结果发现其衰减相对缓慢，腹膜腔内肝素的平均半衰期为10.8±0.93小时。通过免疫和功能方法测定的肝素辅因子抗凝血酶III在开始透析前吸出的残留腹膜液中浓度较低。一般来说，这不到正常血浆值的三分之一，并且随着透析的反复稀释和流出过程，辅因子浓度迅速降至可忽略不计的水平，无法激活任何存在的肝素。腹膜内单次给予10000 U肝素对全身凝血没有影响，因为在随后的6小时内测量时，血浆A-PTT值没有延长。
