[Levels of plasma proteins in patients with ene stage renal failure treated with peritoneal dialysis with an addition of furosemide to dialysis fluid].

This study aimed at evaluating an effect of repeated intraperitoneal furosemide administration on plasma proteins in patients with uremia given the drug to increase intermittent peritoneal dialysis efficiency. Patients (n = 6) dialysed for 48-60 hours per week furosemide was added to dialysis fluid in the dose of 1.2-2.0 g per 1 dialysis weekly for 3 months. A control group consisted of patients (n = 6) dialysed without furosemide. Plasma total proteins, albumin, total globulins, IgG, and IgA were determined in all patients. At the same time, plasma furosemide levels were monitored. A 3-month treatment with dialyses supplemented with furosemide decreased plasma protein levels especially IgG (p < 0.5) in comparison with dialyses without the drug. Furosemide plasma levels remained below ototoxic levels (over 50 micrograms/mL) during the treatment.