Kuźniak J, Grzegorzewska A
Zakładu Analityki Medycznej Katedry Onkologii AM.
Pol Tyg Lek. 1992;47(5-6):123-5.
Our studies aimed at determining a loss of active heparin from the peritoneal cavity after its intraperitoneal administration (250 JU/l of dialysis fluid) in 16 patients treated because of the end-stage renal failure with intermittent peritoneal dialysis and at comparing heparin influx clearance with that of glucose. It has been shown that heparin used in this dose loses 60-70% of its activity after 20-minute equilibration of dialysis fluid in the peritoneal cavity. Heparin influx clearance is higher than that of glucose but it depends on utilization of heparin in peritoneal cavity rather than on its penetration to the blood circulation.
我们的研究旨在确定16例因终末期肾衰竭接受间歇性腹膜透析治疗的患者腹腔内注射肝素（250国际单位/升透析液）后，腹腔内活性肝素的损失情况，并将肝素流入清除率与葡萄糖的流入清除率进行比较。结果表明，以该剂量使用的肝素在腹腔内透析液平衡20分钟后，其活性损失60%-70%。肝素流入清除率高于葡萄糖，但它取决于肝素在腹腔内的利用情况，而非其向血液循环的渗透情况。
