Vázquez J J, Diaz de Otazu R, Guillen F J, Zozaya J, Pardo F J
Diagn Histopathol. 1983 Jan-Mar;6(1):29-37.
We report here on the hepatic lesions produced in 17 alcoholic patients who had received Cyanamide or Disulfiram as aversion therapy. The characteristic lesion consists of cytoplasmic inclusions, similar to Lafora bodies. They are found predominantly in periportal hepatocytes, including those lining the cholangioles. They appear to be persistent but are lost after death of the inclusion-bearing liver-cell when both the inclusion body and the dead hepatocyte are removed by macrophages. As well as the inclusion bodies, portal or periportal inflammation and necrosis of isolated liver-cells are seen. The inflammatory infiltrate is usually denser in the periportal areas and is associated with liver-cell destruction. The inflammation is usually followed by portal fibrosis which can be severe if treatment is prolonged. In one case, in which two biopsies were performed, cirrhosis developed while that patient was on Cyanamide.
我们在此报告17例接受氨甲酰或双硫仑作为厌恶疗法的酒精性患者所产生的肝脏病变。特征性病变包括细胞质内包涵体，类似于拉福拉小体。它们主要见于汇管区周围的肝细胞，包括胆小管内衬的肝细胞。这些包涵体似乎持续存在，但在含包涵体的肝细胞死亡后会消失，此时包涵体和死亡的肝细胞会被巨噬细胞清除。除了包涵体外，还可见门管区或汇管区周围炎症以及单个肝细胞坏死。炎症浸润通常在汇管区周围更为密集，并与肝细胞破坏有关。炎症通常随后会出现门管区纤维化，如果治疗时间延长，纤维化可能会很严重。在1例进行了两次活检的病例中，该患者在服用氨甲酰期间发展为肝硬化。
