Vazquez J J, Guillen F J, Zozaya J, Lahoz M
Liver. 1983 Aug;3(4):225-30. doi: 10.1111/j.1600-0676.1983.tb00872.x.
Cyanamide, a drug frequently used for aversion therapy in chronic alcoholism, induces a liver-cell lesion consisting of cytoplasmic inclusion bodies, structurally similar to those of Lafora. In order to know how frequently the lesion is associated with the intake of this drug, a prospective study was carried out. A biopsy was performed in ten chronic alcoholic patients who had been treated with Cyanamide. Inclusion bodies were present in all patients (7 cases) whose biopsy was taken when they were on Cyanamide and in two other patients whose biopsies were taken 3 and 7 years after discontinuation of the treatment. Inclusion bodies were absent in one case who was treated for a short time and with a small dose and whose biopsy was performed 3 years after cessation of treatment. On the basis of these findings, the lesion may be considered to be predictable. The absence of inclusions in one patient may be explained by their disappearance after cessation of treatment.
氨甲酰，一种常用于慢性酒精中毒厌恶疗法的药物，可诱发一种肝细胞病变，其特征为细胞质内出现包涵体，在结构上与拉福拉小体相似。为了了解这种病变与该药物摄入的关联频率，开展了一项前瞻性研究。对10名接受过氨甲酰治疗的慢性酒精中毒患者进行了活检。所有在服用氨甲酰期间接受活检的患者（7例）以及另外2名在停药3年和7年后接受活检的患者均发现有包涵体。有1例患者接受的是短期小剂量治疗，在停药3年后进行活检，未发现包涵体。基于这些发现，这种病变可被认为是可预测的。1例患者未出现包涵体，可能是因为停药后包涵体消失了。
