Yokoyama A, Sato S, Maruyama K, Nakano M, Takahashi H, Okuyama K, Takagi S, Takagi T, Yokoyama T, Hayashida M
National Institute on Alcoholism, Kurihama National Hospital, Kanagawa, Japan.
Alcohol Clin Exp Res. 1995 Oct;19(5):1307-11. doi: 10.1111/j.1530-0277.1995.tb01616.x.
This is the first study that we are aware of that followed the histopathological progression of the liver disease that was caused by the combination of both chronic alcohol use and cyanamide, an antidipsotropic agent. Two sequential liver biopsy specimens were obtained on 29 alcoholics who relapsed with varying histories of cyanamide treatment. Cyanamide induced ground-glass inclusions (GGIs) in the hepatocytes. Two groups were identified, depending on whether GGIs proliferated or regressed, which was, in turn, found contingent on the duration of cyanamide treatment and the drug-free period. Group 1 included 14 cases in which GGIs either emerged only in the second biopsy specimen or else were increased in the second specimen as compared in the initial specimen. Group 2 composed of 15 cases in which GGIs were either not observed in either specimen or decreased in the second specimen as compared in the initial specimen. Acidophilic bodies were sequentially increased in five cases (36%) of group 1 and in none of group 2. The severity of portal inflammation worsened in 10 cases (71%) of group 1 but in 2 cases (13%) of group 2, although the changes in fibrotic process did not differ between two groups. These differences could not be explained on the basis of the daily ethanol consumption and the length of relapses of the two groups. Thus, when cyanamide-treated alcoholics relapsed, the combined effect of cyanamide and alcohol produced the development of acidophilic bodies and portal inflammation along with the emergence of GGIs.
据我们所知，这是第一项追踪由长期饮酒与戒酒硫（一种抗嗜酒剂）联合导致的肝脏疾病组织病理学进展的研究。对29例有不同戒酒硫治疗史且复发的酗酒者获取了两份连续的肝脏活检标本。戒酒硫在肝细胞中诱导产生毛玻璃样包涵体（GGIs）。根据GGIs是增多还是消退确定了两组，而这又取决于戒酒硫治疗的持续时间和停药期。第1组包括14例，其中GGIs要么仅在第二次活检标本中出现，要么在第二次标本中比初始标本增多。第2组由15例组成，其中在两份标本中均未观察到GGIs，或者在第二次标本中比初始标本减少。嗜酸性小体在第1组的5例（36%）中依次增多，而在第2组中无一例增多。第1组10例（71%）门脉炎症严重程度加重，而第2组为2例（13%），尽管两组纤维化进程的变化无差异。这些差异无法根据两组的每日乙醇摄入量和复发时长来解释。因此，接受戒酒硫治疗的酗酒者复发时，戒酒硫和酒精的联合作用会导致嗜酸性小体和门脉炎症的发展以及GGIs的出现。
