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含钙肾结石患者草酸盐吸收增加的证据。

Evidence of increased oxalate absorption in patients with calcium-containing renal stones.

作者信息

Hodgkinson A

出版信息

Clin Sci Mol Med. 1978 Mar;54(3):291-4. doi: 10.1042/cs0540291.

DOI:10.1042/cs0540291
PMID:630804
Abstract
  1. The possible roles of the diet and of intestinal absorption in the increased excretion of oxalate by patients with renal calcium stones have been studied. 2. Dietary surveys showed that the mean daily intake of oxalic acid by stone-formers was not significantly different from that of non-stone-formers. 3. The mean urinary excretion of oxalate, expressed as an oxalate/creatinine molar ratio, was significantly reduced by fasting, the change being more marked in the stone-formers than in the normal subjects. Moreover, fasting abolished the difference in mean oxalate/creatinine ratios between stone-formers and control subjects. 4. These results are compatible with the hypothesis that the small increases in urinary oxalate excretion which occur in some idiopathic calcium oxalate stone-formers are due to increased absorption of oxalate from the intestine, which may be due to a reduction in intraluminal calcium concentration.
摘要
  1. 已对饮食和肠道吸收在肾钙结石患者草酸盐排泄增加中可能发挥的作用进行了研究。2. 饮食调查表明,结石形成者每日草酸的平均摄入量与非结石形成者相比无显著差异。3. 以草酸盐/肌酐摩尔比表示的草酸盐平均尿排泄量在禁食时显著降低,结石形成者的变化比正常受试者更明显。此外,禁食消除了结石形成者与对照受试者之间草酸盐/肌酐平均比值的差异。4. 这些结果与以下假设相符:一些特发性草酸钙结石形成者尿草酸盐排泄量的小幅增加是由于肠道对草酸盐的吸收增加,这可能是由于管腔内钙浓度降低所致。

相似文献

1
Evidence of increased oxalate absorption in patients with calcium-containing renal stones.含钙肾结石患者草酸盐吸收增加的证据。
Clin Sci Mol Med. 1978 Mar;54(3):291-4. doi: 10.1042/cs0540291.
2
Intestinal oxalate and calcium absorption in recurrent renal stone formers and healthy subjects.复发性肾结石患者与健康受试者的肠道草酸和钙吸收情况。
Scand J Urol Nephrol. 1989;23(1):55-9. doi: 10.1080/00365599.1989.11690431.
3
Hyperoxaluria in idiopathic calcium stone disease: further evidence of intestinal hyperabsorption of oxalate.特发性钙结石病中的高草酸尿症:草酸肠道过度吸收的进一步证据。
Clin Sci (Lond). 1982 Oct;63(4):381-5. doi: 10.1042/cs0630381.
4
Oxalate metabolism in renal stone disease with special reference to calcium metabolism and intestinal absorption.肾结石病中的草酸盐代谢,特别涉及钙代谢和肠道吸收。
Scand J Urol Nephrol Suppl. 1989;119:1-53.
5
Dietary treatment of urinary risk factors for renal stone formation. A review of CLU Working Group.肾结石形成的尿液危险因素的饮食治疗。CLU工作组综述
Arch Ital Urol Androl. 2015 Jul 7;87(2):105-20. doi: 10.4081/aiua.2015.2.105.
6
Postprandial hyperoxaluria and intestinal oxalate absorption in idiopathic renal stone disease.特发性肾结石病中的餐后高草酸尿症和肠道草酸吸收
J Urol. 1984 Oct;132(4):650-5. doi: 10.1016/s0022-5347(17)49808-9.
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Influence of the calcium content of the diet on the incidence of mild hyperoxaluria in idiopathic renal stone formers.饮食中钙含量对特发性肾结石患者轻度高草酸尿症发病率的影响。
Am J Nephrol. 1985;5(1):40-4. doi: 10.1159/000166901.
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The variability and dietary dependence of urinary oxalate excretion in recurrent calcium stone formers.复发性草酸钙结石患者尿草酸排泄的变异性及饮食依赖性
Ann Clin Biochem. 1987 Jul;24 ( Pt 4):385-90. doi: 10.1177/000456328702400407.
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The urinary response to an oral oxalate load in recurrent calcium stone formers.复发性草酸钙结石患者口服草酸盐负荷后的尿液反应。
J Urol. 2003 Jun;169(6):2030-3. doi: 10.1097/01.ju.0000062527.37579.49.
10
[Renal oxalate excretion following oral oxalate load in patients with urinary calculus disease and healthy controls].[尿路结石病患者和健康对照者口服草酸盐负荷后的肾草酸盐排泄]
Hinyokika Kiyo. 1986 Dec;32(12):1773-9.

引用本文的文献

1
Influence of a high-oxalate diet on intestinal oxalate absorption.高草酸盐饮食对肠道草酸盐吸收的影响。
World J Urol. 2005 Nov;23(5):324-9. doi: 10.1007/s00345-005-0028-0. Epub 2005 Nov 5.
2
Oxalate and chloride absorption by the rabbit colon: sensitivity to metabolic and anion transport inhibitors.兔结肠对草酸盐和氯化物的吸收:对代谢及阴离子转运抑制剂的敏感性
Gut. 1984 Mar;25(3):232-7. doi: 10.1136/gut.25.3.232.
3
Metabolic causes of nephrolithiasis.肾结石的代谢性病因。
West J Med. 1983 Apr;138(4):541-5.
4
Urolithiasis research--where is it going?尿石症研究——路在何方?
Urol Res. 1985;13(4):157-9. doi: 10.1007/BF00261816.
5
A case-control study of dietary intake of renal stone patients. II. Urine biochemistry and stone analysis.肾结石患者饮食摄入的病例对照研究。II. 尿液生物化学与结石分析。
Urol Res. 1986;14(2):75-82. doi: 10.1007/BF00257892.
6
Effects of oral pyridoxine upon plasma and 24-hour urinary oxalate levels in normal subjects and stone formers with idiopathic hypercalciuria.口服吡哆醇对正常受试者及特发性高钙尿症结石形成者血浆和24小时尿草酸水平的影响。
Urol Res. 1990;18(6):393-6. doi: 10.1007/BF00297371.