Reddy D, Lancaster J R, Cornforth D P
Science. 1983 Aug 19;221(4612):769-70. doi: 10.1126/science.6308761.
Vegetative cells of Clostridium botulinum were shown to contain iron-sulfur proteins that react with added nitrite to form iron-nitric oxide complexes, with resultant destruction of the iron-sulfur cluster. Inactivation of iron-sulfur enzymes (especially ferredoxin) by binding of nitric oxide would almost certainly inhibit growth, and thus is probably the mechanism of botulinal inhibition by nitrite in foods.
肉毒梭菌的营养细胞被证明含有铁硫蛋白，这些铁硫蛋白会与添加的亚硝酸盐反应形成铁一氧化氮复合物，从而导致铁硫簇的破坏。一氧化氮的结合使铁硫酶（尤其是铁氧化还原蛋白）失活几乎肯定会抑制生长，因此这可能是亚硝酸盐抑制食品中肉毒杆菌的机制。
