Quaglino D, Di Leonardo G, Ginaldi L, Lalli G, Limoncelli P
Clinica Medica II, Università, L'Aquila.
Recenti Prog Med. 1996 Oct;87(10):491-9.
Patients treated with radiation and cytotoxic agents for a variety of neoplastic conditions develop with increased frequency a secondary leukaemia, usually a form of acute myeloblastic leukaemia. The authors illustrate and discuss the various morphological and cytobiological which characterize the "preleukaemic phase", and which comprise myelodysplastic alterations, cytochemical abnormalities, concerning the presence of glycogen and free iron in the red cell series, as well as a number of changes in enzymatic activities in the myeloid series, cytokinetic changes, indicative of accumulation of cells in G0 and G1, cytogenetic non-random abnormalities, involving specific chromosomes, and finally in vitro cultures which show a reduction in colony formation. The authors underline the differences between primary and secondary preleukaemic myelodysplastic states, consisting in the presence in the latter of frequent hypocellularity, fibrosis and almost invariability a clear involvement of multiple cell lines.
因各种肿瘤疾病接受放疗和细胞毒性药物治疗的患者，继发白血病（通常为急性髓细胞白血病）的频率增加。作者阐述并讨论了“白血病前期”的各种形态学和细胞生物学特征，包括骨髓发育异常改变、细胞化学异常（涉及红细胞系列中糖原和游离铁的存在）、髓系系列中多种酶活性的变化、细胞动力学变化（表明细胞在G0和G1期积累）、涉及特定染色体的细胞遗传学非随机异常，以及最终体外培养显示集落形成减少。作者强调了原发性和继发性白血病前期骨髓发育异常状态之间的差异，后者常表现为细胞减少、纤维化，且几乎总是多个细胞系明显受累。
