通过将二高-δ-亚麻酸与人多形核白细胞一起孵育产生的白三烯。
Leukotrienes produced by incubation of dihomo-delta-linolenic acid with human polymorphonuclear leukocytes.
作者信息
Jubiz W, Nolan G
出版信息
Biochem Biophys Res Commun. 1983 Jul 29;114(2):855-62. doi: 10.1016/0006-291x(83)90860-4.
Two new leukotrienes, 8,15-dihydroxy-9,11,13-icosatrienoic acid (8,15-LTB3) and 14,15-dihydroxy-8,10,12-icosatrienoic acid (14,15-LTB3) were identified in incubations of human polymorphonuclear leukocytes with dihomo-delta-linolenic acid (8,11,14-icosatrienoic acid). The yield of these compounds was very low (0.5% of the total radioactivity) and did not increase with indomethacin alone or in combination with ionophore A-23187. Stereochemistry and biologic activity of the two leukotrienes remain to be established.
在人多形核白细胞与二高-δ-亚麻酸（8,11,14-二十碳三烯酸）的孵育过程中，鉴定出了两种新的白三烯，即8,15-二羟基-9,11,13-二十碳三烯酸（8,15-LTB3）和14,15-二羟基-8,10,12-二十碳三烯酸（14,15-LTB3）。这些化合物的产量非常低（占总放射性的0.5%），单独使用吲哚美辛或与离子载体A-23187联合使用时产量均未增加。这两种白三烯的立体化学和生物活性仍有待确定。
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