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胰岛素基因附近的DNA插入序列与青少年成年起病型糖尿病无关。

DNA insertion sequences near the insulin gene are not associated with maturity-onset diabetes of young people.

作者信息

Owerbach D, Thomsen B, Johansen K, Lamm L U, Nerup J

出版信息

Diabetologia. 1983 Jul;25(1):18-20. doi: 10.1007/BF00251890.

DOI:10.1007/BF00251890
PMID:6309587
Abstract

The association between DNA insertion sequences located near the insulin gene and the dominantly inherited maturity-onset diabetes of young people was studied in a large family. The distribution of the restriction fragments was compatible with Mendelian segregation. However, no linkage was found between the DNA insertion sequences and this form of diabetes.

摘要

在一个大家庭中研究了位于胰岛素基因附近的DNA插入序列与年轻人显性遗传的成年型糖尿病之间的关联。限制性片段的分布符合孟德尔分离定律。然而，未发现DNA插入序列与这种糖尿病形式之间存在连锁关系。

相似文献

1
DNA insertion sequences near the insulin gene are not associated with maturity-onset diabetes of young people.胰岛素基因附近的DNA插入序列与青少年成年起病型糖尿病无关。
Diabetologia. 1983 Jul;25(1):18-20. doi: 10.1007/BF00251890.
2
Maturity onset diabetes of the young is not linked to the insulin gene.青年发病的成年型糖尿病与胰岛素基因无关。
Br Med J (Clin Res Ed). 1983 Feb 19;286(6365):590-2. doi: 10.1136/bmj.286.6365.590.
3
DNA insertion sequences near the insulin gene affect glucose regulation.
Lancet. 1982 Apr 17;1(8277):880-3. doi: 10.1016/s0140-6736(82)92152-3.
4
Pedigree analysis of the 5' flanking region of the insulin gene in familial diabetes mellitus.家族性糖尿病中胰岛素基因5'侧翼区域的系谱分析
Metabolism. 1986 Jan;35(1):13-7. doi: 10.1016/0026-0495(86)90089-2.
5
Insulin gene in diabetes. Analysis through RFLP.糖尿病中的胰岛素基因。通过限制性片段长度多态性分析。
Diabetes Care. 1990 Mar;13(3):364-74. doi: 10.2337/diacare.13.3.364.
6
[Polymorphism of the DNA restriction fragment length flanking the insulin gene. A genetic marker for diabetic mellitus or atherosclerosis?].[胰岛素基因侧翼DNA限制性片段长度多态性。糖尿病或动脉粥样硬化的遗传标记？]
Ugeskr Laeger. 1985 Jun 24;147(26):2065-71.
7
Genetic polymorphisms in the analysis of diabetes mellitus.糖尿病分析中的基因多态性
Monogr Atheroscler. 1985;13:32-43.
8
Insulin gene analysis in a family with maturity-onset diabetes of the young.一个青年发病的成年型糖尿病家族的胰岛素基因分析。
Diabetes. 1985 Feb;34(2):108-14. doi: 10.2337/diab.34.2.108.
9
Restriction fragment length polymorphism of the insulin gene in diabetes mellitus.糖尿病中胰岛素基因的限制性片段长度多态性
Diabetes. 1982 Mar;31(3):275-7. doi: 10.2337/diab.31.3.275.
10
Polymorphisms in the 5'-flanking region of the insulin gene and non-insulin-dependent diabetes.胰岛素基因5'侧翼区域的多态性与非胰岛素依赖型糖尿病
Clin Sci (Lond). 1984 Apr;66(4):383-8. doi: 10.1042/cs0660383.

引用本文的文献

1
Polymorphism in the 5' flanking region of the human insulin gene. Relationships with noninsulin-dependent diabetes mellitus, glucose and insulin concentrations, and diabetes treatment in the Pima Indians.人类胰岛素基因5'侧翼区的多态性。与皮马印第安人非胰岛素依赖型糖尿病、血糖和胰岛素浓度以及糖尿病治疗的关系。
J Clin Invest. 1984 Dec;74(6):2129-35. doi: 10.1172/JCI111638.
2
Insulin-gene flanking sequences, diabetes mellitus and atherosclerosis: a review.
Diabetologia. 1985 Aug;28(8):556-64. doi: 10.1007/BF00281989.
3
Possible correlation between non-insulin dependent diabetes mellitus (NIDDM) and restriction fragment length polymorphism (RFLP) of the 5'-flanking region of insulin gene in Korean diabetic population.韩国糖尿病患者群体中非胰岛素依赖型糖尿病（NIDDM）与胰岛素基因5'-侧翼区限制性片段长度多态性（RFLP）之间的可能相关性。

本文引用的文献

1
The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type.椭圆形红细胞增多症基因与Rh血型之间连锁关系的检测与评估。
Am J Hum Genet. 1956 Jun;8(2):80-96.
2
No evidence for linkage between HLA and maturity onset type of diabetes in young people.无证据表明HLA与青少年成年起病型糖尿病之间存在连锁关系。
Diabetologia. 1982 Jul;23(1):16-8. doi: 10.1007/BF00257723.
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Restriction fragment length polymorphism of the insulin gene in diabetes mellitus.糖尿病中胰岛素基因的限制性片段长度多态性
Korean J Intern Med. 1987 Jul;2(2):140-6. doi: 10.3904/kjim.1987.2.2.140.
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Linkage analysis of the human insulin receptor gene and maturity onset diabetes of the young.人类胰岛素受体基因与青年发病型成年糖尿病的连锁分析。
Diabetologia. 1987 Aug;30(8):641-7. doi: 10.1007/BF00277322.
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Diabetes mellitus, atherosclerosis, and the 5' flanking polymorphism of the human insulin gene.
J Inherit Metab Dis. 1986;9 Suppl 1:98-110. doi: 10.1007/BF01800863.
6
The genetic predisposition to fibrocalculous pancreatic diabetes.纤维钙化性胰腺糖尿病的遗传易感性。
Diabetologia. 1989 Jan;32(1):45-51. doi: 10.1007/BF00265403.
7
Multipoint linkage analysis of the short arm of chromosome 11 in non-insulin dependent diabetes including maturity onset diabetes of youth.对11号染色体短臂进行多点连锁分析，该研究涵盖非胰岛素依赖型糖尿病，包括青年发病的成年型糖尿病。
Hum Genet. 1992 May;89(2):207-12. doi: 10.1007/BF00217125.
Diabetes. 1982 Mar;31(3):275-7. doi: 10.2337/diab.31.3.275.
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Polymorphism in the 5' flanking region of the human insulin gene: a genetic marker for non-insulin-dependent diabetes.人类胰岛素基因5'侧翼区的多态性：非胰岛素依赖型糖尿病的一种遗传标记。
N Engl J Med. 1983 Jan 13;308(2):65-71. doi: 10.1056/NEJM198301133080202.
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Variation in the sequence and modification state of the human insulin gene flanking regions.人胰岛素基因侧翼区域序列及修饰状态的变异
Nucleic Acids Res. 1982 Apr 10;10(7):2225-40. doi: 10.1093/nar/10.7.2225.
6
Polymorphic DNA region adjacent to the 5' end of the human insulin gene.人类胰岛素基因5'端相邻的多态性DNA区域。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5759-63. doi: 10.1073/pnas.78.9.5759.
7
Polymorphism in the 5'-flanking region of the human insulin gene and its possible relation to type 2 diabetes.人类胰岛素基因5'侧翼区域的多态性及其与2型糖尿病的可能关系。
Science. 1981 Sep 4;213(4512):1117-20. doi: 10.1126/science.6267694.
8
The insulin gene is located on chromosome 11 in humans.胰岛素基因位于人类的11号染色体上。
Nature. 1980 Jul 3;286(5768):82-4. doi: 10.1038/286082a0.
9
Possible association between DNA sequences flanking the insulin gene and atherosclerosis.胰岛素基因侧翼的DNA序列与动脉粥样硬化之间可能存在的关联。
Lancet. 1982 Dec 11;2(8311):1291-3. doi: 10.1016/s0140-6736(82)91505-7.
10
DNA insertion sequences near the insulin gene affect glucose regulation.
Lancet. 1982 Apr 17;1(8277):880-3. doi: 10.1016/s0140-6736(82)92152-3.