Bell J I, Wainscoat J S, Old J M, Chlouverakis C, Keen H, Turner R C, Weatherall D J
Br Med J (Clin Res Ed). 1983 Feb 19;286(6365):590-2. doi: 10.1136/bmj.286.6365.590.
Maturity onset diabetes of the young is inherited as an autosomal dominant condition. Two families with the disease were studied to determine whether the inheritance of this type of diabetes was linked to the insulin gene. A cloned insulin gene probe was hybridised to DNA from the family members and the insulin gene on each chromosome identified by a different fragment length polymorphism. The results showed no linkage between the insulin gene and the inheritance of maturity onset diabetes of the young.
青年发病的成年型糖尿病以常染色体显性遗传病的方式遗传。对两个患有该疾病的家族进行了研究，以确定这种类型糖尿病的遗传是否与胰岛素基因有关。将一个克隆的胰岛素基因探针与家族成员的DNA杂交，并通过不同的片段长度多态性来识别每条染色体上的胰岛素基因。结果表明，胰岛素基因与青年发病的成年型糖尿病的遗传之间没有关联。
