• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

韩国糖尿病患者群体中非胰岛素依赖型糖尿病（NIDDM）与胰岛素基因5'-侧翼区限制性片段长度多态性（RFLP）之间的可能相关性。

Possible correlation between non-insulin dependent diabetes mellitus (NIDDM) and restriction fragment length polymorphism (RFLP) of the 5'-flanking region of insulin gene in Korean diabetic population.

作者信息

Kim S W, Yang I M, Kim J W, Kim Y S, Choi Y K

出版信息

Korean J Intern Med. 1987 Jul;2(2):140-6. doi: 10.3904/kjim.1987.2.2.140.

DOI:10.3904/kjim.1987.2.2.140
PMID:2908729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4534927/
Abstract

Restriction fragment length polymorphism (RFLP) is a new and precise method for the detection of the disease on the molecular level. The genetic background of Non-insulin dependant diabetes mellitus (NIDDM) has been strongly suggested, but its occurrences are obvious for other expession factors. We first investigated insulin gene polymorphism in twenty-nine Korea NIDDM patients and 11 non-diabetic controls. We found 91 percent and 86 percent of the genotype 1/1 in diabetics and controls respectively. Also genotype 1/3 was found 9 percent and 14 percent each in both groups. Genotype 3/3 revealed 0 percent in two groups. Four acromegalics who had secondary DM showed only genotype 1/1. These findings showed that class 3 allele(2.4 kb) was a weak genetic marker of NIDDM, and had a faint correlation.

摘要

限制性片段长度多态性（RFLP）是一种在分子水平上检测疾病的新的精确方法。非胰岛素依赖型糖尿病（NIDDM）的遗传背景已得到有力提示，但其发生明显受其他表达因素影响。我们首先对29例韩国NIDDM患者和11名非糖尿病对照者的胰岛素基因多态性进行了研究。我们发现糖尿病患者和对照者中基因型1/1分别占91%和86%。此外，两组中基因型1/3均占9%和14%。基因型3/3在两组中均为0%。4例患有继发性糖尿病的肢端肥大症患者仅表现为基因型1/1。这些结果表明，3类等位基因（2.4 kb）是NIDDM的一个弱遗传标记，且相关性较弱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e714/4534927/a5ecdb3a809d/kjim-2-2-140-2f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e714/4534927/1590cfb0bc3d/kjim-2-2-140-2f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e714/4534927/a2c0310a8cbd/kjim-2-2-140-2f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e714/4534927/45a8566dbd4d/kjim-2-2-140-2f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e714/4534927/a5ecdb3a809d/kjim-2-2-140-2f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e714/4534927/1590cfb0bc3d/kjim-2-2-140-2f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e714/4534927/a2c0310a8cbd/kjim-2-2-140-2f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e714/4534927/45a8566dbd4d/kjim-2-2-140-2f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e714/4534927/a5ecdb3a809d/kjim-2-2-140-2f4.jpg

相似文献

1
Possible correlation between non-insulin dependent diabetes mellitus (NIDDM) and restriction fragment length polymorphism (RFLP) of the 5'-flanking region of insulin gene in Korean diabetic population.韩国糖尿病患者群体中非胰岛素依赖型糖尿病（NIDDM）与胰岛素基因5'-侧翼区限制性片段长度多态性（RFLP）之间的可能相关性。
Korean J Intern Med. 1987 Jul;2(2):140-6. doi: 10.3904/kjim.1987.2.2.140.
2
Polymorphic locus in the 5'-flanking region of human insulin gene and non-insulin-dependent diabetes mellitus.人类胰岛素基因5'侧翼区域的多态性位点与非胰岛素依赖型糖尿病
J Formos Med Assoc. 1990 Nov;89(11):965-8.
3
Insulin gene in diabetes. Analysis through RFLP.糖尿病中的胰岛素基因。通过限制性片段长度多态性分析。
Diabetes Care. 1990 Mar;13(3):364-74. doi: 10.2337/diacare.13.3.364.
4
Restriction fragment length polymorphism of the insulin gene region in Japanese diabetic and non-diabetic subjects.
Diabetologia. 1985 Dec;28(12):911-3. doi: 10.1007/BF00703135.
5
The genotypic distribution among non-insulin-dependent diabetes mellitus (NIDDM) patients of a restriction fragment length polymorphism.非胰岛素依赖型糖尿病（NIDDM）患者中一种限制性片段长度多态性的基因型分布。
Am J Hum Genet. 1984 Mar;36(2):466-70.
6
Non-insulin-dependent diabetes mellitus and the 5' hypervariable region of the insulin gene in two South African Indian families.两个南非印度家庭中的非胰岛素依赖型糖尿病与胰岛素基因的5'高变区
S Afr Med J. 1987 Feb 7;71(3):174-8.
7
Low frequency of 5'-flanking insertion of human insulin gene in Japanese non-insulin-dependent diabetic subjects.日本非胰岛素依赖型糖尿病患者中人类胰岛素基因5'-侧翼插入的低频率
Diabetes Care. 1986 Jul-Aug;9(4):365-9. doi: 10.2337/diacare.9.4.365.
8
High frequency of class 3 allele in the human insulin gene in Japanese type 2 (non-insulin-dependent) diabetic patients with a family history of diabetes.在有糖尿病家族史的日本2型（非胰岛素依赖型）糖尿病患者中，人类胰岛素基因3类等位基因的高频率。
Diabetologia. 1986 Jun;29(6):402-4. doi: 10.1007/BF00903353.
9
Restriction-fragment-length-polymorphisms close to the human insulin gene on chromosome 11 and their possible relation to diabetes mellitus in a GDR population.位于11号染色体上靠近人类胰岛素基因的限制性片段长度多态性及其与德意志民主共和国人群中糖尿病的可能关系。
Biomed Biochim Acta. 1988;47(4-5):311-5.
10
Bgl II-restriction fragment length polymorphism of the insulin receptor gene in patients with type-II diabetes mellitus.
Biomed Biochim Acta. 1990;49(12):1233-5.

引用本文的文献

1
Polymorphism of glucokinase gene in non-insulin dependent diabetes mellitus.非胰岛素依赖型糖尿病中葡萄糖激酶基因的多态性
Korean J Intern Med. 1994 Jan;9(1):25-31. doi: 10.3904/kjim.1994.9.1.25.

本文引用的文献

1
Chemistry of insulin; determination of the structure of insulin opens the way to greater understanding of life processes.胰岛素的化学性质；胰岛素结构的确定为更深入理解生命过程开辟了道路。
Science. 1959 May 15;129(3359):1340-4. doi: 10.1126/science.129.3359.1340.
2
Diabetes in identical twins. A study of 200 pairs.同卵双胞胎中的糖尿病。一项对200对双胞胎的研究。
Diabetologia. 1981 Feb;20(2):87-93. doi: 10.1007/BF00262007.
3
The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences.人类胰岛素基因附近的高度多态性区域由简单串联重复序列组成。
Nature. 1982 Jan 7;295(5844):31-5. doi: 10.1038/295031a0.
4
Localization of the human insulin gene to the distal end of the short arm of chromosome 11.人类胰岛素基因定位于11号染色体短臂的末端。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4458-60. doi: 10.1073/pnas.78.7.4458.
5
The insulin gene is located on the short arm of chromosome 11 in humans.胰岛素基因位于人类第11号染色体的短臂上。
Diabetes. 1981 Mar;30(3):267-70. doi: 10.2337/diab.30.3.267.
6
Diabetic hypertriglyceridaemia and related 5' flanking polymorphism of the human insulin gene.糖尿病性高甘油三酯血症与人胰岛素基因5'侧翼多态性的相关性
Br Med J (Clin Res Ed). 1984 Jan 14;288(6411):96-9. doi: 10.1136/bmj.288.6411.96.
7
Maturity onset diabetes of the young is not linked to the insulin gene.青年发病的成年型糖尿病与胰岛素基因无关。
Br Med J (Clin Res Ed). 1983 Feb 19;286(6365):590-2. doi: 10.1136/bmj.286.6365.590.
8
Polymorphism in the 5' flanking region of the human insulin gene. Relationships with noninsulin-dependent diabetes mellitus, glucose and insulin concentrations, and diabetes treatment in the Pima Indians.人类胰岛素基因5'侧翼区的多态性。与皮马印第安人非胰岛素依赖型糖尿病、血糖和胰岛素浓度以及糖尿病治疗的关系。
J Clin Invest. 1984 Dec;74(6):2129-35. doi: 10.1172/JCI111638.
9
A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus.人类胰岛素基因附近的一个多态性位点与胰岛素依赖型糖尿病相关。
Diabetes. 1984 Feb;33(2):176-83. doi: 10.2337/diab.33.2.176.
10
DNA insertion sequences near the insulin gene are not associated with maturity-onset diabetes of young people.胰岛素基因附近的DNA插入序列与青少年成年起病型糖尿病无关。
Diabetologia. 1983 Jul;25(1):18-20. doi: 10.1007/BF00251890.