Argyris B F, Reif A E
Cancer Res. 1981 Mar;41(3):839-44.
C57BL/6J mice were used both for induction of osteogenic sarcomas by injection of 90Sr and for induction of sarcomas and carcinomas by injection of 9,10-dimethyl-1,2-benzanthracene. The osteogenic sarcomas had a relatively long induction period; they possessed low immunogenicity and failed to activate splenic suppressor cells either in the original tumor-bearing host or in mice bearing transplanted osteogenic sarcomas. In contrast, and in agreement with previous work, 9,10-dimethyl-1,2-benzanthracene-induced tumors had a relatively short induction period; they possessed high immunogenicity and activated splenic suppressor cells in mice bearing transplanted tumors. These results suggest the possibility that the immunogenicity of tumors correlates with the ability of tumors to activate suppressor cells.
C57BL/6J小鼠被用于通过注射90Sr诱导骨肉瘤，以及通过注射9,10-二甲基-1,2-苯并蒽诱导肉瘤和癌。骨肉瘤的诱导期相对较长；它们具有低免疫原性，并且在原始荷瘤宿主或携带移植性骨肉瘤的小鼠中均未能激活脾抑制细胞。相比之下，与先前的研究一致，9,10-二甲基-1,2-苯并蒽诱导的肿瘤诱导期相对较短；它们具有高免疫原性，并在携带移植性肿瘤的小鼠中激活脾抑制细胞。这些结果提示肿瘤的免疫原性与肿瘤激活抑制细胞的能力相关的可能性。
