Devasagayam T P, Pushpendran C K, Eapen J
Mech Ageing Dev. 1983 Mar-Apr;21(3-4):365-75. doi: 10.1016/0047-6374(83)90053-2.
Significant changes are observed in wet weight, microsomal protein content and enzymes of purified rough and smooth microsomes of liver during postnatal development and ageing of female Wistar rats. Protein content of total microsomes increases up to 15 days of age and remains steady during subsequent development, unlike that of rough and smooth microsomes which shows changes throughout the same period. Activities of cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase increase during the period of maturation and decline during senescence. The decrease during senescence is at different rates in the two microsomal fractions. Microsomal glucose-6-phosphatase, but not adenosine triphosphatase, shows a similar increase during development and decrease during senescence.
在雌性Wistar大鼠出生后发育和衰老过程中，观察到肝脏湿重、微粒体蛋白含量以及纯化的粗面和滑面微粒体酶有显著变化。总微粒体的蛋白含量在15日龄前增加，在随后的发育过程中保持稳定，而粗面和滑面微粒体的蛋白含量在同一时期呈现变化。细胞色素P-450、细胞色素b5和NADPH-细胞色素c还原酶的活性在成熟期间增加，在衰老期间下降。衰老期间的下降在两个微粒体组分中的速率不同。微粒体葡萄糖-6-磷酸酶，而非三磷酸腺苷酶，在发育过程中呈现类似的增加，在衰老过程中下降。
