蛙心房中，铯对钾电流iK1及卡巴胆碱诱导的钾电流iCch的阻断作用。
Block by Cs of K current iK1 and of carbachol induced K current iCch in frog atrium.
作者信息
Argibay J A, Dutey P, Ildefonse M, Ojeda C, Rougier O, Tourneur Y
出版信息
Pflugers Arch. 1983 Jun 1;397(4):295-9. doi: 10.1007/BF00580264.
PMID:6310482
Abstract
- In frog atrium, Cs ions block both the inward rectifier iK1 and the carbachol induced K current iCch. 2. Both iK1 and iCch display a high affinity for Cs with a K0.5 of 4 X 10(-5) M for iK1 and of 8 X 10(-5) M for iCch at V = -50 mV. 3. Block of both iK1 and iCch is strongly voltage dependent. When fitted by the block model of Woodhull (1973), delta is greater than 1 for the two currents. 4. From these similarities, action of Cch on frog atrium K permeability could be interpreted as a modification of iK1.
摘要
- 在蛙心房中，铯离子可阻断内向整流钾电流iK1和卡巴胆碱诱导的钾电流iCch。2. iK1和iCch对铯均表现出高亲和力，在V = -50 mV时，iK1的半数抑制浓度（K0.5）为4×10⁻⁵ M，iCch的K0.5为8×10⁻⁵ M。3. iK1和iCch的阻断都强烈依赖电压。当用伍德胡尔（1973年）的阻断模型拟合时，这两种电流的δ均大于1。4. 基于这些相似性，卡巴胆碱对蛙心房钾通透性的作用可解释为对iK1的修饰。
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