de Champlain J P, Kinsella T D, Fritzler M J, Werschler B
Rheumatol Int. 1983;3(1):23-7. doi: 10.1007/BF00541228.
Evidence for intra-articular immunity to Epstein-Barr virus (EBV) was sought in synovial fluids (SF) and SF phagocytes derived from patients with and without rheumatoid arthritis (RA). Antibody titres to EBV were not significantly different in SF of 32 RA and 25 non-RA patients. Whereas the majority of RA patients (69%) showed Ig-containing complexes (IC) in SF phagocytes, fluorescent antibody staining of these by anti-EBV serum was negative except with 6 RA patients. Extended analysis of the SF phagocytes of the latter, however, showed no EBV specificity in their IC, suggesting that these represented non-specific "pseudo-IC'. These studies do not support a role for EBV-containing IC in the propagation of rheumatoid synovitis and demonstrate that not all immunofluorescent inclusions in RA phagocytes (ragocytes) represent immune complexes.
研究人员在患有和未患类风湿性关节炎（RA）患者的滑液（SF）及SF吞噬细胞中寻找针对爱泼斯坦-巴尔病毒（EBV）的关节内免疫证据。32例RA患者和25例非RA患者的SF中，EBV抗体滴度无显著差异。虽然大多数RA患者（69%）的SF吞噬细胞中显示含免疫球蛋白的复合物（IC），但除6例RA患者外，用抗EBV血清对这些复合物进行荧光抗体染色均为阴性。然而，对后6例患者的SF吞噬细胞进行深入分析发现，其IC中不存在EBV特异性，提示这些代表非特异性“假IC”。这些研究不支持含EBV的IC在类风湿性滑膜炎传播中的作用，并表明并非RA吞噬细胞（类风湿细胞）中的所有免疫荧光包涵体都代表免疫复合物。
