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本文引用的文献

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Antigenic analysis of polioviruses by kinetic studies of serum neutralization.通过血清中和动力学研究对脊髓灰质炎病毒进行抗原分析。
Virology. 1959 Jan;7(1):45-58. doi: 10.1016/0042-6822(59)90176-x.
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A study of the basic aspects of neutralization of two animal viruses, western equine encephalitis virus and poliomyelitis virus.一项关于两种动物病毒——西部马脑炎病毒和脊髓灰质炎病毒——中和作用基本方面的研究。
Virology. 1956 Apr;2(2):162-205. doi: 10.1016/0042-6822(56)90017-4.
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Use of recombinant human antibody fragments for detection of cytomegalovirus antigenemia.重组人抗体片段用于检测巨细胞病毒抗原血症
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Detection and typing of herpes simplex viruses by using recombinant immunoglobulin fragments produced in bacteria.利用细菌中产生的重组免疫球蛋白片段检测和分型单纯疱疹病毒。
J Clin Microbiol. 1997 Jun;35(6):1504-9. doi: 10.1128/jcm.35.6.1504-1509.1997.
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Topically applied human recombinant monoclonal IgG1 antibody and its Fab and F(ab')2 fragments protect mice from vaginal transmission of HSV-2.局部应用的人重组单克隆IgG1抗体及其Fab和F(ab')2片段可保护小鼠免受HSV-2的阴道传播感染。
Virology. 1996 Nov 1;225(1):213-5. doi: 10.1006/viro.1996.0589.
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Treatment of hypogammaglobulinaemia with intravenous immunoglobulin, 1973-93.1973年至1993年静脉注射免疫球蛋白治疗低丙种球蛋白血症
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Protection of nude mice by passive immunization with a type-common human recombinant monoclonal antibody against HSV.用针对单纯疱疹病毒（HSV）的一种通用型人重组单克隆抗体进行被动免疫对裸鼠的保护作用。
Virology. 1996 Jan 1;215(1):101-6. doi: 10.1006/viro.1996.0011.
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Intravenous immune globulin for the prevention of infections in children with symptomatic human immunodeficiency virus infection.
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9
Anti-glycoprotein B monoclonal antibody protects T cell-depleted mice against herpes simplex virus infection by inhibition of virus replication at the inoculated mucous membranes.抗糖蛋白B单克隆抗体通过抑制接种黏膜处的病毒复制，保护T细胞耗竭的小鼠免受单纯疱疹病毒感染。
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10
Neutralization of animal viruses.动物病毒的中和作用
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一种具有高治疗潜力的单纯疱疹病毒通用型人重组单克隆抗体的特性分析。

Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential.

作者信息

De Logu A, Williamson R A, Rozenshteyn R, Ramiro-Ibañez F, Simpson C D, Burton D R, Sanna P P

机构信息

Departments of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA.

出版信息

J Clin Microbiol. 1998 Nov;36(11):3198-204. doi: 10.1128/JCM.36.11.3198-3204.1998.

DOI:10.1128/JCM.36.11.3198-3204.1998
PMID:9774565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105301/
Abstract

We report the characterization of a type-common human recombinant monoclonal antibody previously isolated by antigen selection from a phage-displayed combinatorial antibody library established from a herpes simplex virus (HSV)-seropositive individual. Competition with well-characterized murine monoclonal antibodies and immunodetection of gD truncations revealed that this antibody recognizes the group Ib antigenic site of glycoprotein D, a highly conserved and protective type-common determinant. To our knowledge, this is the first human group Ib monoclonal antibody ever described. The antibody also displayed first-order neutralization kinetics and a high neutralization rate constant, was capable of completely inhibiting syncytium formation by a fusogenic strain of HSV type 1, and efficiently neutralized low-passage clinical isolates of both HSV serotypes. Taken together with our earlier observations of the in vivo antiviral activities of this human recombinant antibody in animal models of HSV infection, the present results support the high therapeutic potential of this antibody.

摘要

我们报告了一种类型通用的人重组单克隆抗体的特性，该抗体先前是通过抗原筛选从一名单纯疱疹病毒（HSV）血清阳性个体建立的噬菌体展示组合抗体文库中分离出来的。与特征明确的鼠单克隆抗体竞争以及对gD截短体的免疫检测表明，该抗体识别糖蛋白D的Ib组抗原位点，这是一个高度保守且具有保护作用的类型通用决定簇。据我们所知，这是有史以来描述的第一种人Ib组单克隆抗体。该抗体还表现出一级中和动力学和高中和速率常数，能够完全抑制1型HSV融合株的合胞体形成，并有效中和两种HSV血清型的低传代临床分离株。结合我们早期在HSV感染动物模型中对这种人重组抗体体内抗病毒活性的观察结果，目前的结果支持了该抗体具有很高的治疗潜力。