Rickard K A, Foland B B, Detamore C M, Coates T D, Grosfeld J L, White N M, Weetman R M, Provisor A J, Loghmani E S, Oei T O, Yu P L, Baehner R L
Am J Clin Nutr. 1983 Sep;38(3):445-56. doi: 10.1093/ajcn/38.3.445.
The effectiveness of central parenteral nutrition (CPN) versus peripheral parenteral nutrition (PPN) plus enteral nutrition in reversing protein-energy malnutrition was evaluated in 19 children (nine CPN, 10 PPN) with advanced neuroblastoma or Wilms' tumor. Weekly dietary, anthropometric, and biochemical measurements were compared for 15 patients (eight CPN, seven PPN) who completed more than 25 days of nutrition support. The groups had similar mean energy and protein intakes (CPN: 95 +/- 5% of healthy children, 2.5 +/- 0.3 g/kg; PPN: 102 +/- 5% of healthy children, 2.9 +/- 0.3 g/kg). Increases in weight (p less than 0.001), subscapular skinfold thickness (p less than 0.001), albumin (p less than 0.05), and transferrin (p less than 0.05) for the first 28 days were significant and did not differ between groups. Fever, sepsis, elevated SGOT, and severe anemia occurred with both CPN and PPN. PPN resulted in subcutaneous infiltrations and more psychological trauma. PPN with enteral nutrition seems most appropriate for short term intravenous nutrition support or as a temporary substitute for CPN; CPN is preferred for long-term support.
在19名患有晚期神经母细胞瘤或肾母细胞瘤的儿童（9名接受中心静脉营养，10名接受外周静脉营养）中，评估了中心静脉营养（CPN）与外周静脉营养（PPN）加肠内营养在逆转蛋白质-能量营养不良方面的效果。对15名完成超过25天营养支持的患者（8名接受CPN，7名接受PPN）的每周饮食、人体测量和生化指标进行了比较。两组的平均能量和蛋白质摄入量相似（CPN：为健康儿童的95±5%，2.5±0.3 g/kg；PPN：为健康儿童的102±5%，2.9±0.3 g/kg）。前28天体重（p<0.001）、肩胛下皮褶厚度（p<0.001）、白蛋白（p<0.05）和转铁蛋白（p<0.05）的增加具有显著性，且两组间无差异。CPN和PPN均出现发热、败血症、谷草转氨酶升高和严重贫血。PPN导致皮下浸润和更多心理创伤。PPN加肠内营养似乎最适合短期静脉营养支持或作为CPN的临时替代方案；长期支持首选CPN。
