对逆转录病毒诱导的加德纳综合征细胞转化的遗传易感性。
Inherited susceptibility to retrovirus-induced transformation of Gardner syndrome cells.
作者信息
Rasheed S, Rhim J S, Gardner E J
出版信息
Am J Hum Genet. 1983 Sep;35(5):919-31.
Abstract
Skin fibroblasts from patients with Gardner syndrome (GS), those with familial polyposis coli (FPC), and spouse or unrelated controls were karyotyped and tested for various growth properties including susceptibility to transformation by viral or chemical agents. Our results indicated that based on the higher susceptibility to retrovirus-induced transformation and chromosomal aneuploidy, the GS and FPC cells could be distinguished from those of the general population with more than 70% accuracy. However, much work is in order before any biological assay can be used for clinical diagnosis of GS or FPC patients.
摘要
对患有加德纳综合征（GS）、家族性结肠息肉病（FPC）的患者以及其配偶或无关对照的皮肤成纤维细胞进行了核型分析，并测试了各种生长特性，包括对病毒或化学试剂诱导转化的敏感性。我们的结果表明，基于对逆转录病毒诱导转化和染色体非整倍体的更高敏感性，GS和FPC细胞能够与普通人群的细胞区分开来，准确率超过70%。然而，在任何生物学检测可用于GS或FPC患者的临床诊断之前，还有许多工作要做。
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