亨廷顿病患者皮肤成纤维细胞的病毒易感性。
Viral susceptibility of skin fibroblasts from patients with Huntington disease.
作者信息
Miller C A, Rasheed S
出版信息
Am J Hum Genet. 1981 Mar;33(2):197-202.
Abstract
Cultured skin fibroblasts from patients with Huntington disease (HD) and age-matched controls were tested for susceptibility to vesicular stomatitis virus (VSV) and transformation by Kirsten mouse sarcoma virus (KiMSV). The HD and control cells could not be distinguished on the basis of viral replication, plaque morphology, virus yield, or susceptibility to transformation by KiMSV. These findings suggest that the HD gene product, if expressed within peripheral tissue, does not selectively alter or interfere with viral replication.
摘要
对亨廷顿病（HD）患者及年龄匹配的对照者的培养皮肤成纤维细胞进行了检测，以确定其对水疱性口炎病毒（VSV）的易感性以及被 Kirsten 小鼠肉瘤病毒（KiMSV）转化的情况。基于病毒复制、噬斑形态、病毒产量或对 KiMSV 转化的易感性，无法区分 HD 细胞和对照细胞。这些发现表明，HD 基因产物如果在外周组织中表达，并不会选择性地改变或干扰病毒复制。
相似文献
1
Viral susceptibility of skin fibroblasts from patients with Huntington disease.亨廷顿病患者皮肤成纤维细胞的病毒易感性。
Am J Hum Genet. 1981 Mar;33(2):197-202.
2
Enhanced sensitivity of skin fibroblasts from neurofibromatosis patients to transformation by the Kirsten murine sarcoma virus. A potential laboratory assay for individuals at risk of cancer.神经纤维瘤病患者的皮肤成纤维细胞对劳氏肉瘤病毒转化的敏感性增强。一种针对癌症高危个体的潜在实验室检测方法。
Ann N Y Acad Sci. 1986;486:403-12. doi: 10.1111/j.1749-6632.1986.tb48093.x.
3
Hydrocortisone promotes the neodifferentiation of Kirsten murine sarcoma virus transformed human skin fibroblasts to adipose cells: relevance to oncogenic mechanisms.氢化可的松促进 Kirsten 小鼠肉瘤病毒转化的人皮肤成纤维细胞向脂肪细胞的新分化：与致癌机制的相关性。
Exp Cell Biol. 1986;54(1):25-33. doi: 10.1159/000163340.
4
Interferon inhibits transformation by murine sarcoma viruses before integration of provirus.在原病毒整合之前，干扰素可抑制鼠肉瘤病毒的转化作用。
Nature. 1980 Nov 6;288(5786):93-5. doi: 10.1038/288093a0.
5
Transformation/neodifferentiation of human skin fibroblasts by acute oncornaviruses and dexamethasone.急性肿瘤病毒与地塞米松对人皮肤成纤维细胞的转化/新分化作用
Exp Cell Biol. 1988;56(6):311-20. doi: 10.1159/000163497.
6
5-Azacytidine inhibits adipocytic conversion of human skin fibroblasts by Kirsten murine sarcoma virus and dexamethasone.5-氮杂胞苷可抑制由 Kirsten 小鼠肉瘤病毒和地塞米松诱导的人皮肤成纤维细胞的脂肪细胞转化。
Exp Cell Biol. 1987;55(5):276-80. doi: 10.1159/000163427.
7
Transformation of rat thyroid epithelial cells by Kirsten murine sarcoma virus.柯斯顿鼠肉瘤病毒对大鼠甲状腺上皮细胞的转化作用。
Int J Cancer. 1981 Nov 15;28(5):655-62. doi: 10.1002/ijc.2910280519.
8
Inherited susceptibility to retrovirus-induced transformation of Gardner syndrome cells.对逆转录病毒诱导的加德纳综合征细胞转化的遗传易感性。
Am J Hum Genet. 1983 Sep;35(5):919-31.
9
Susceptibility of xeroderma pigmentosum cells to transformation by murine and feline sarcoma viruses.着色性干皮病细胞对鼠肉瘤病毒和猫肉瘤病毒转化的易感性。
Cancer Res. 1976 Sep;36(9 pt.1):3294-9.
10
Replication of reticuloendotheliosis viruses in cell culture: chronic infection.网状内皮组织增生症病毒在细胞培养中的复制：慢性感染
J Gen Virol. 1975 Jun;27(3):267-74. doi: 10.1099/0022-1317-27-3-267.
引用本文的文献
1
The ups and downs of Huntington disease research.亨廷顿舞蹈症研究的起伏
Am J Hum Genet. 1981 Mar;33(2):314-7.
2
The current state of research with peripheral tissues in Huntington disease.亨廷顿舞蹈病周围组织的研究现状
Hum Genet. 1984;66(2-3):115-31. doi: 10.1007/BF00286586.
3
Inherited susceptibility to retrovirus-induced transformation of Gardner syndrome cells.对逆转录病毒诱导的加德纳综合征细胞转化的遗传易感性。
Am J Hum Genet. 1983 Sep;35(5):919-31.
本文引用的文献
1
2
Skin fibroblasts in Huntington disease.亨廷顿舞蹈症中的皮肤成纤维细胞。
Am J Hum Genet. 1981 Mar;33(2):187-96.
3
Structure and function relationships of the envelope of measles virus.麻疹病毒包膜的结构与功能关系
Med Microbiol Immunol. 1974;160(2-3):143-54. doi: 10.1007/BF02121721.
4
Human chromosome 21 dosage: effect on the expression of the interferon induced antiviral state.人类21号染色体剂量：对干扰素诱导的抗病毒状态表达的影响
Science. 1974 Oct 4;186(4158):61-3. doi: 10.1126/science.186.4158.61.
5
Viral probes of aging in the human diploid cell strain WI-38.人类二倍体细胞株WI-38衰老的病毒探针
Proc Soc Exp Biol Med. 1974 Jun;146(2):385-90. doi: 10.3181/00379727-146-38110.
6
Analysis of virus replication in ageing human fibroblast cultures.衰老人类成纤维细胞培养物中病毒复制的分析。
Nature. 1973 Oct 12;245(5424):316-9. doi: 10.1038/245316a0.
7
Differences in susceptibility of human cells to mouse sarcoma virus.人类细胞对小鼠肉瘤病毒易感性的差异。
J Natl Cancer Inst. 1971 Jul;47(1):65-73.
8
Transformation and virus growth by murine sarcoma viruses in human cells.鼠肉瘤病毒在人类细胞中的转化及病毒生长
Nature. 1970 Jan 31;225(5231):458-9. doi: 10.1038/225458a0.
9
Increased susceptibility of Down's syndrome fibroblasts to transformation by SV40.唐氏综合征成纤维细胞对SV40转化的易感性增加。
Proc Soc Exp Biol Med. 1967 Apr;124(4):1232-6. doi: 10.3181/00379727-124-31974.
10
Susceptibility of human diploid fibroblast strains to transformation by SV40 virus.人类二倍体成纤维细胞株对SV40病毒转化的易感性。
Science. 1966 Sep 9;153(3741):1252-4. doi: 10.1126/science.153.3741.1252.
Zotero 插件