Schultz R O, Peters M A, Sobocinski K, Nassif K, Schultz K J
Am J Ophthalmol. 1983 Sep;96(3):368-71. doi: 10.1016/s0002-9394(14)77829-8.
In a study of 102 patients (64 women and 38 men; 63 whites and 39 nonwhites; 77 with adult-onset disease and 25 with juvenile-onset disease), the data, after being adjusted for age, showed that diabetic peripheral neuropathy was associated with diabetic keratopathy. The strongest predictor of both keratopathy and corneal fluorescein staining was vibration perception threshold in the toes (P less than .01); the severity of keratopathy was directly related to the degree of diminution of peripheral sensation. Other predictors of keratopathy were reduced tear break-up time (P less than .03), the type of diabetes (P less than .01), and metabolic status, shown by fasting C-peptide levels (P less than .01). No significant relationships were found between keratopathy and tear glucose levels, endothelial cell densities, corneal thickness, or duration of disease.
在一项针对102名患者（64名女性和38名男性；63名白人和39名非白人；77名成年发病患者和25名青少年发病患者）的研究中，经年龄调整后的数据显示，糖尿病周围神经病变与糖尿病性角膜病变相关。角膜病变和角膜荧光素染色的最强预测指标是脚趾的振动觉阈值（P<0.01）；角膜病变的严重程度与周围感觉减退程度直接相关。角膜病变的其他预测指标包括泪膜破裂时间缩短（P<0.03）、糖尿病类型（P<0.01）以及空腹C肽水平所显示的代谢状态（P<0.01）。未发现角膜病变与泪液葡萄糖水平、内皮细胞密度、角膜厚度或病程之间存在显著关系。
