Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Surv Ophthalmol. 2020 Sep-Oct;65(5):513-529. doi: 10.1016/j.survophthal.2020.02.005. Epub 2020 Feb 22.
Ocular complications from diabetes mellitus are common. Diabetic keratopathy, the most frequent clinical condition affecting the human cornea, is a potentially sight-threatening condition caused mostly by epithelial disturbances that are of clinical and research attention because of their severity. Diabetic keratopathy exhibits several clinical manifestations, including persistent corneal epithelial erosion, superficial punctate keratopathy, delayed epithelial regeneration, and decreased corneal sensitivity, that may lead to compromised visual acuity or permanent vision loss. The limited amount of clinical studies makes it difficult to fully understand the pathobiology of diabetic keratopathy. Effective therapeutic approaches are elusive. We summarize the clinical manifestations of diabetic keratopathy and discuss available treatments and up-to-date research studies in an attempt to provide a thorough overview of the disorder.
糖尿病的眼部并发症很常见。糖尿病性角膜病变是最常见的影响人眼角膜的临床病症，是一种潜在的致盲性疾病，主要由上皮功能紊乱引起，因其严重性而受到临床和研究关注。糖尿病性角膜病变表现出多种临床表现，包括持续性角膜上皮糜烂、浅层点状角膜病变、上皮再生延迟和角膜敏感性降低，这可能导致视力受损或永久性视力丧失。由于临床研究数量有限，因此很难全面了解糖尿病性角膜病变的病理生物学。有效的治疗方法难以捉摸。我们总结了糖尿病性角膜病变的临床表现，并讨论了现有的治疗方法和最新的研究，试图全面了解这种疾病。
