[3-羟基吡啶类抗氧化剂对环磷酸腺苷磷酸二酯酶活性的影响]
[Effect of antioxidants of the 3-hydroxypyridine class on cyclic 3', 5'-adenosine monophosphate phosphodiesterase activity].
作者信息
Smirnov L D, Malykhina L S, Lazarevich V G, Fedorov N A
出版信息
Biull Eksp Biol Med. 1983 Sep;96(9):40-2.
PMID:6311309
Abstract
It was shown that derivatives of oxypyridine inhibit activity of 3,5-AMP phosphodiesterase I and II from the rabbit heart. 2-ethyl-6-methyl-3-oxypyridine and proxypheine inhibited 3,5-AMP phosphodiesterase activity in human lymphocytes substantially higher than theophilline widely used in clinical practice.
摘要
结果表明，氧化吡啶衍生物可抑制兔心脏中3,5-AMP磷酸二酯酶I和II的活性。2-乙基-6-甲基-3-氧化吡啶和丙苯碱对人淋巴细胞中3,5-AMP磷酸二酯酶活性的抑制作用明显高于临床实践中广泛使用的茶碱。
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